SUMO1/sentrin Specific Protease 6 (SENP6) (C-Term) Peptid
SENP6
Reaktivität: Human, Maus
Wirt: Synthetic
BP, WB
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- Target Alle SENP6 Produkte
- SENP6 (SUMO1/sentrin Specific Protease 6 (SENP6))
- Protein Region
- C-Term
- Spezies
- Human, Maus
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Quelle
- Synthetic
- Applikation
- Blocking Peptide (BP), Western Blotting (WB)
- Sequenz
- LAVVCFPGLE KPKYEPNPHY HENAVMQKTP SAEDSCVSSA SEMGACSQNS
- Produktmerkmale
- This is a synthetic peptide designed for use in combination with anti-Senp6 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Aufreinigung
- Purified
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- Applikationshinweise
- Each Investigator should determine their own optimal working dilution for specific applications.
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
-
- Format
- Lyophilized
- Rekonstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Konzentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handhabung
- Avoid repeated freeze-thaw cycles.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- SENP6 (SUMO1/sentrin Specific Protease 6 (SENP6))
- Hintergrund
-
Senp6 is a protease that deconjugates SUMO1, SUMO2 and SUMO3 from targeted proteins. Senp6 rocesses preferentially poly-SUMO2 and poly-SUMO3 chains, but does not efficiently process SUMO1, SUMO2 and SUMO3 precursors. Senp6 deconjugates SUMO1 from RXRA, leading to transcriptional activation. Senp6 is involved in chromosome alignment and spindle assembly, by regulating the kinetochore CENPH-CENPI-CENPK complex. Senp6 desumoylates PML and CENPI, protecting them from degradation by the ubiquitin ligase RNF4, which targets polysumoylated proteins for proteasomal degradation and desumoylates also RPA1, thus preventing recruitment of RAD51 to the DNA damage foci to initiate DNA repair through homologous recombination.
Alias Symbols: 2810017C20Rik, E130319N12Rik, MGC38009, Susp1, mKIAA0797
Protein Size: 1132 - Molekulargewicht
- 127 kDa
- Gen-ID
- 215351
- NCBI Accession
- NM_146003, NP_666115
- UniProt
- Q6P7W0
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