Rhotekin (RTKN) (Middle Region) Peptid
RTKN
Reaktivität: Human
Wirt: Synthetic
BP, WB
Produktnummer ABIN983307
Kurzübersicht für Rhotekin (RTKN) (Middle Region) Peptid (ABIN983307)
Target
Rhotekin (RTKN)
Spezies
Human
Quelle
Synthetic
Applikation
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- Middle Region
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Produktmerkmale
- This is a synthetic peptide designed for use in combination with anti-RTKN antibody (Catalog #: ARP56211_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Aufreinigung
- Purified
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Applikationshinweise
- Each Investigator should determine their own optimal working dilution for specific applications.
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Lyophilized
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Rekonstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Konzentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handhabung
- Avoid repeated freeze-thaw cycles.
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Lagerung
- -20 °C
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Informationen zur Lagerung
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Rhotekin (RTKN)
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Hintergrund
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RTKN mediates Rho signaling to activate NF-kappa-B and may confer increased resistance to apoptosis to cells in gastric tumorigenesis. RTKN may play a novel role in the organization of septin structures.This gene encodes a scaffold protein that interacts with GTP-bound Rho proteins. Binding of this protein inhibits the GTPase activity of Rho proteins. This protein may interfere with the conversion of active, GTP-bound Rho to the inactive GDP-bound form by RhoGAP. Rho proteins regulate many important cellular processes, including cytokinesis, transcription, smooth muscle contraction, cell growth and transformation. Dysregulation of the Rho signal transduction pathway has been implicated in many forms of cancer. Alternative splicing results in multiple transcript variants encoding different isoforms.
Alias Symbols: -
Protein Interaction Partner: RHOA,RHOA,RHOA,RHOA,RTN4R,GOPC,RAC2,RHOA,RHOC,SMURF1,TAX1BP3,TGFBR1,RHOA,RHOA
Protein Size: 563 -
Molekulargewicht
- 63 kDa
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Gen-ID
- 6242
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NCBI Accession
- NM_001015055, NP_001015055
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UniProt
- Q9BST9
Target
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