Recombination Activating Gene 1 (RAG1) (C-Term) Peptid
RAG1
Reaktivität: Maus
Wirt: Synthetic
BP, WB
Produktnummer ABIN982623
Kurzübersicht für Recombination Activating Gene 1 (RAG1) (C-Term) Peptid (ABIN982623)
Target
RAG1
(Recombination Activating Gene 1 (RAG1))
Spezies
Maus
Quelle
Synthetic
Applikation
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- C-Term
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Sequenz
- IIERDGSIGA WASEGNESGN KLFRRFRKMN ARQSKCYEME DVLKHHWLYT
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Produktmerkmale
- This is a synthetic peptide designed for use in combination with anti-Rag1 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Aufreinigung
- Purified
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Applikationshinweise
- Each Investigator should determine their own optimal working dilution for specific applications.
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Lyophilized
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Rekonstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Konzentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handhabung
- Avoid repeated freeze-thaw cycles.
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Lagerung
- -20 °C
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Informationen zur Lagerung
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- RAG1 (Recombination Activating Gene 1 (RAG1))
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Hintergrund
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As a catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break between the RSS and the adjacent coding segment. RAG2 is not a catalytic component but is required for all known catalytic activities.
Alias Symbols: Rag-1
Protein Interaction Partner: Nfkb1,Rel,Rela
Protein Size: 1040 -
Molekulargewicht
- 119 kDa
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Gen-ID
- 19373
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NCBI Accession
- NM_009019, NP_033045
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UniProt
- P15919
Target
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