Presenilin 1 (PSEN1) (Middle Region) Peptid

Details zu Produkt Nr. ABIN982321, Anbieter: Anmelden zum Anzeigen
Proteinname
  • pre1
  • psen
  • zfPS1
  • zf-PS1
  • ad3
  • fad
  • ps1
  • s182
  • X-PS-beta
  • X-PS-alpha
  • AD3
  • FAD
  • PS-1
  • PS1
  • S182
  • Ad3h
  • presenilin 1
  • presenilin 1 L homeolog
  • psen1
  • PSEN1
  • Psen1
  • psen1.L
Protein Region
Middle Region
Spezies
Human
9
4
2
2
2
1
Quelle
Synthetic
Applikation
Blocking Peptide (BP), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blotting (WB)
Optionen
Hersteller
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Hersteller Produkt- Nr.
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Geblockter Antikörper anti-Presenilin 1 Antikörper (PSEN1) (Middle Region) (ABIN2787886)
Sequenz EGDPEAQRRV SKNSKYNAES TERESQDTVA ENDDGGFSEE WEAQRDSHLG
Produktmerkmale This is a synthetic peptide designed for use in combination with anti-PSEN1 Antibody(ARP58941_P050),. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
Reinigung Purified
Proteinname
Hintergrund Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1, PSEN2) or in the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene, the full-length nature of only some have been determined.

Alias Symbols: AD3, FAD, PS1, S182, PS-1

Protein Interaction Partner: APH1A,APP,APP,APP,APP,CTNNB1,CTNND2,NCSTN,STX1A,STX5,CASP1,CASP3,CASP4,CASP7,APBA1,APH1A,APH1B,APP,BACE1,BCL2,BCL2L1,CASP1,CASP3,CASP4,CASP6,CASP7,CASP8,CDH1,CDK5,CIB1,CTNNA1,CTNNB1,CTNND1,CTNND2,DLL1,DOCK3,EFNB2,ERN1,FBXW7,FLNA,FLNB,GDI1,GFAP,GSK3B,HERPU

Protein Size: 467
Molekulargewicht 53 kDa
Gen-ID 5663
NCBI Accession NM_000021, NP_000012
UniProt P49768
Applikations-hinweise Each Investigator should determine their own optimal working dilution for specific applications.
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Lyophilized
Rekonstitution Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
Konzentration 1 mg/mL
Buffer Final peptide concentration is 1 mg/mL in PBS.
Handhabung Avoid repeated freeze-thaw cycles.
Lagerung -20 °C
Informationen zur Lagerung For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.