PR Domain Containing 16 (PRDM16) (Middle Region) Peptid
PRDM16
Reaktivität: Human
Wirt: Synthetic
BP, WB
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- Target Alle PRDM16 Produkte
- PRDM16 (PR Domain Containing 16 (PRDM16))
- Protein Region
- Middle Region
- Spezies
- Human
-
Quelle
- Synthetic
- Applikation
- Blocking Peptide (BP), Western Blotting (WB)
- Sequenz
- LNHTQDAKLP SPLGNPALPL VSAVSNSSQG TTAAAGPEEK FESRLEDSCV
- Produktmerkmale
- This is a synthetic peptide designed for use in combination with anti-PRDM16 Antibody(ARP33260_P050),. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Aufreinigung
- Purified
-
-
- Applikationshinweise
- Each Investigator should determine their own optimal working dilution for specific applications.
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
-
- Format
- Lyophilized
- Rekonstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Konzentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handhabung
- Avoid repeated freeze-thaw cycles.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
-
- Target
- PRDM16 (PR Domain Containing 16 (PRDM16))
- Hintergrund
-
The reciprocal translocation t(1,3)(p36,q21) occurs in a subset of myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). This gene is located near the 1p36.3 breakpoint and has been shown to be specifically expressed in the t(1:3)(p36,q21)-positive MDS/AML. The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal PR domain. The translocation results in the overexpression of a truncated version of this protein that lacks the PR domain, which may play an important role in the pathogenesis of MDS and AML. Alternatively spliced transcript variants encoding distinct isoforms have been reported.
Alias Symbols: KIAA1675, MEL1, PFM13
Protein Interaction Partner: INADL
Protein Size: 1275 - Molekulargewicht
- 140 kDa
- Gen-ID
- 63976
- NCBI Accession
- NM_022114, NP_071397
- UniProt
- Q9HAZ2
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