PMS2
(PMS2 Postmeiotic Segregation Increased 2 (S. Cerevisiae) (PMS2))
Protein Region
Middle Region
Spezies
Human
Quelle
Synthetic
Applikation
Blocking Peptide (BP), Western Blotting (WB)
Produktmerkmale
This is a synthetic peptide designed for use in combination with anti-PMS2 antibody (Catalog #: ARP56117_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
PMS2 is involved in DNA mismatch repair. It forms a heterodimer with MLH1 and this complex interacts with other complexes bound to mismatched bases. Mutations in this gene are associated with hereditary nonpolyposis colorectal cancer, Turcot syndrome, and are a cause of supratentorial primitive neuroectodermal tumors.This gene is one of the PMS2 gene family members found in clusters on chromosome 7. The product of this gene is involved in DNA mismatch repair. It forms a heterodimer with MLH1 and this complex interacts with other complexes bound to mismatched bases. Mutations in this gene are associated with hereditary nonpolyposis colorectal cancer, Turcot syndrome, and are a cause of supratentorial primitive neuroectodermal tumors. Alternatively spliced transcript variants have been observed for this gene.
Alias Symbols: HNPCC4, PMS2CL, PMSL2
Protein Interaction Partner: EXO1,MLH1,EXO1,MLH1,AIFM1,ATAD3A,BRCA2,BRIP1,COPB1,COPG,COPG2,CYLD,DDB1,EXO1,KPNA2,KPNB1,MCM3,MLH1,MMS19,MSH2,MSH3,MSH6,MTMR15,NSUN2,PCNA,PIK3C2A,PPP2CA,PRKDC,PSD2,PSD3,PSMC1,PSMC2,PSMC3,PSMC6,PSMD5,RFC2,RUVBL1,RUVBL2,SMARCA4,UBC,UBR5,XPO1