Procollagen-Lysine 2-Oxoglutarate 5-Dioxygenase 2 (PLOD2) (Middle Region) Peptid

Details zu Produkt Nr. ABIN981868, Anbieter: Anmelden zum Anzeigen
Proteinname
  • D530025C14Rik
  • LH2
  • Plod-2
  • TLH
  • procollagen lysine, 2-oxoglutarate 5-dioxygenase 2
  • procollagen-lysine,2-oxoglutarate 5-dioxygenase 2
  • Plod2
  • PLOD2
Protein Region
Middle Region
Spezies
Human
1
1
Quelle
Synthetic
Applikation
Blocking Peptide (BP), Immunohistochemistry (IHC), Western Blotting (WB)
Optionen
Hersteller
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Hersteller Produkt- Nr.
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Geblockter Antikörper anti-PLOD2 Antikörper (Procollagen-Lysine 2-Oxoglutarate 5-Dioxygenase 2) (Middle Region) (ABIN2775556)
Produktmerkmale This is a synthetic peptide designed for use in combination with anti-PLOD2 antibody (Catalog #: ARP42731_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
Reinigung Purified
Hintergrund PLOD2 forms hydroxylysine residues in -Xaa-Lys-Gly- sequences in collagens. These hydroxylysines serve as sites of attachment for carbohydrate units and are essential for the stability of the intermolecular collagen cross-links.The protein encoded by this gene is a membrane-bound homodimeric enzyme that is localized to the cisternae of the rough endoplasmic reticulum. The enzyme (cofactors iron and ascorbate) catalyzes the hydroxylation of lysyl residues in collagen-like peptides. The resultant hydroxylysyl groups are attachment sites for carbohydrates in collagen and thus are critical for the stability of intermolecular crosslinks. Some patients with Ehlers-Danlos syndrome type VIB have deficiencies in lysyl hydroxylase activity. Mutations in the coding region of this gene are associated with Bruck syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms.

Alias Symbols: LH2, TLH

Protein Interaction Partner: PLOD2,HNRNPA1,PLOD2,RUVBL2

Protein Size: 758
Molekulargewicht 84 kDa
Gen-ID 5352
NCBI Accession NM_182943, NP_891988
Applikationshinweise Each Investigator should determine their own optimal working dilution for specific applications.
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Lyophilized
Rekonstitution Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
Konzentration 1 mg/mL
Buffer Final peptide concentration is 1 mg/mL in PBS.
Handhabung Avoid repeated freeze-thaw cycles.
Lagerung -20 °C
Informationen zur Lagerung For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.