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phosphodiesterase 6B, CGMP-Specific, Rod, beta (PDE6B) (N-Term) Peptid

PDE6B Reaktivität: Human Wirt: Synthetic BP, WB

Produktnummer ABIN981515

Kurzübersicht für phosphodiesterase 6B, CGMP-Specific, Rod, beta (PDE6B) (N-Term) Peptid (ABIN981515)

Target

PDE6B (phosphodiesterase 6B, CGMP-Specific, Rod, beta (PDE6B))

Spezies

Human

Quelle

Synthetic

Applikation

Blocking Peptide (BP), Western Blotting (WB)

Protein Region

N-Term

Sequenz

LSMPIVNKKE EIVGVATFYN RKDGKPFDEQ DEVLMESLTQ FLGWSVMNTD

Produktmerkmale

This is a synthetic peptide designed for use in combination with anti-PDE6B Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.

Aufreinigung

Purified
phosphodiesterase 6B, CGMP-Specific, Rod, beta (PDE6B) (C-Term) peptide
PDE6B Reaktivität: Human Wirt: Synthetic BP, WB

phosphodiesterase 6B, CGMP-Specific, Rod, beta (PDE6B) peptide
PDE6B Reaktivität: Human, Rind (Kuh), Maus, Schwein, Ratte Wirt: Synthetic BP, WB, ICo, IDe

Applikationshinweise

Each Investigator should determine their own optimal working dilution for specific applications.

Beschränkungen

Nur für Forschungszwecke einsetzbar
Format

Lyophilized

Rekonstitution

Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.

Konzentration

1 mg/mL

Buffer

Final peptide concentration is 1 mg/mL in PBS.

Handhabung

Avoid repeated freeze-thaw cycles.

Lagerung

-20 °C

Informationen zur Lagerung

For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
Target

PDE6B (phosphodiesterase 6B, CGMP-Specific, Rod, beta (PDE6B))

Hintergrund

Photon absorption triggers a signaling cascade in rod photoreceptors that activates cGMP phosphodiesterase (PDE), resulting in the rapid hydrolysis of cGMP, closure of cGMP-gated cation channels, and hyperpolarization of the cell. PDE is a peripheral membrane heterotrimeric enzyme made up of alpha, beta, and gamma subunits. This gene encodes the beta subunit. Mutations in this gene result in retinitis pigmentosa and autosomal dominant congenital stationary night blindness. Multiple transcript variants encoding different isoforms have been found for this gene.

Alias Symbols: CSNB3, CSNBAD2, PDEB, RP40, rd1

Protein Size: 575

Molekulargewicht

63 kDa

Gen-ID

5158

NCBI Accession

NM_001145292, NP_001138764

UniProt

E7ETT3

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