Poly(rC) Binding Protein 1 (PCBP1) Peptid
PCBP1
Reaktivität: Human
Wirt: Synthetic
BP, WB
Produktnummer ABIN981426
Kurzübersicht für Poly(rC) Binding Protein 1 (PCBP1) Peptid (ABIN981426)
Target
PCBP1
(Poly(rC) Binding Protein 1 (PCBP1))
Spezies
Human
Quelle
Synthetic
Applikation
Blocking Peptide (BP), Western Blotting (WB)
-
-
Produktmerkmale
- This is a synthetic peptide designed for use in combination with anti-PCBP1 antibody (Catalog #: ARP40630_T100). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
-
Aufreinigung
- Purified
-
-
-
-
Applikationshinweise
- Each Investigator should determine their own optimal working dilution for specific applications.
-
Beschränkungen
- Nur für Forschungszwecke einsetzbar
-
-
-
Format
- Lyophilized
-
Rekonstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
-
Konzentration
- 1 mg/mL
-
Buffer
- Final peptide concentration is 1 mg/mL in PBS.
-
Handhabung
- Avoid repeated freeze-thaw cycles.
-
Lagerung
- -20 °C
-
Informationen zur Lagerung
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
-
-
- PCBP1 (Poly(rC) Binding Protein 1 (PCBP1))
-
Hintergrund
-
PCBP1 appears to be multifunctional. It along with PCBP-2 and hnRNPK corresponds to the major cellular poly(rC)-binding protein. It contains three K-homologous (KH) domains which may be involved in RNA binding. This protein together with PCBP-2 also functions as translational coactivators of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES and promote poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure. It has also been implicated in translational control of the 15-lipoxygenase mRNA, human Papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. PCBP1 is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability.This intronless gene is thought to be generated by retrotransposition of a fully processed PCBP-2 mRNA. This gene and PCBP-2 has paralogues PCBP3 and PCBP4 which is thought to arose as a result of duplication events of entire genes. The protein encoded by this gene appears to be multifunctional. It along with PCBP-2 and hnRNPK corresponds to the major cellular poly(rC)-binding proteins. It contains three K-homologous (KH) domains which may be involved in RNA binding. This encoded protein together with PCBP-2 also functions as translational coactivators of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES and promote poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure. It has also been implicated in translational control of the 15-lipoxygenase mRNA, human Papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. The encoded protein is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability.
Alias Symbols: HNRPX, HNRPE1, hnRNP-X, hnRNP-E1
Protein Interaction Partner: CELF2,CELF3,EWSR1,GNB2,HNRNPD,HNRNPK,HNRPLL,LMNA,MATR3,NOVA1,PABPC1,PCBP2,PCBP4,PDLIM7,PTBP1,PUF60,QKI,RALY,RBM11,RBM42,SRSF3,TCERG1,TSC22D4,UGP2,ZNF384,RUVBL1,RUVBL2,TAF10,TCERG1
Protein Size: 356 -
Molekulargewicht
- 39 kDa
-
Gen-ID
- 5093
-
NCBI Accession
- NM_006196, NP_006187
-
UniProt
- Q15365
Target
-
Sie sind hier:
