Neuregulin 1 (NRG1) Peptid
NRG1
Reaktivität: Human
Wirt: Synthetic
BP, WB
Produktnummer ABIN980958
Kurzübersicht für Neuregulin 1 (NRG1) Peptid (ABIN980958)
Target
Neuregulin 1 (NRG1)
Spezies
Human
Quelle
Synthetic
Applikation
Blocking Peptide (BP), Western Blotting (WB)
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Produktmerkmale
- This is a synthetic peptide designed for use in combination with anti-NRG1 antibody (Catalog #: ARP46957_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Aufreinigung
- Purified
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Applikationshinweise
- Each Investigator should determine their own optimal working dilution for specific applications.
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Lyophilized
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Rekonstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Konzentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handhabung
- Avoid repeated freeze-thaw cycles.
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Lagerung
- -20 °C
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Informationen zur Lagerung
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Neuregulin 1 (NRG1)
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Hintergrund
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Neuregulin 1 (NRG1) interacts with the NEU/ERBB2 receptor tyrosine kinase to increase its phosphorylation on tyrosine residues.Neuregulin 1 (NRG1) was originally identified as a 44-kD glycoprotein that interacts with the NEU/ERBB2 receptor tyrosine kinase to increase its phosphorylation on tyrosine residues. It is known that an extraordinary variety of different isoforms are produced from the NRG1 gene by alternative splicing. These isoforms include heregulins (HRGs), glial growth factors (GGFs) and sensory and motor neuron-derived factor (SMDF). They are tissue-specifically expressed and differ significantly in their structure. The HRG isoforms all contain immunoglobulin (Ig) and epidermal growth factor-like (EGF-like) domains. GGF and GGF2 isoforms contain a kringle-like sequence plus Ig and EGF-like domains, and the SMDF isoform shares only the EGF-like domain with other isoforms. The receptors for all NRG1 isoforms are the ERBB family of tyrosine kinase transmembrane receptors. Through interaction with ERBB receptors, NRG1 isoforms induce the growth and differentialtion of epithelial, neuronal, glial, and other types of cells.
Alias Symbols: ARIA, GGF, GGF2, HGL, HRG, HRG1, HRGA, NDF, SMDF, MST131
Protein Interaction Partner: ERBB3,ADAM19,EGF,ERBB3,ERBB4,IKZF4,LIMK1,DLG4,EGFR,ERBB2,ERBB3,ERBB4,IKZF4,LIMK1
Protein Size: 296 -
Molekulargewicht
- 32 kDa
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Gen-ID
- 3084
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NCBI Accession
- NM_013959, NP_039253
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UniProt
- Q15491
Target
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