GTPase NRas (NRAS) (Middle Region) Peptid
NRAS
Reaktivität: Human
Wirt: Synthetic
BP, WB
Produktnummer ABIN980946
150,78 €
Zzgl. Versandkosten 20,00 € und MwSt
100 μg
Lieferung nach:
Deutschland
Lieferung in 15 bis 22 Werktagen
Kurzübersicht für GTPase NRas (NRAS) (Middle Region) Peptid (ABIN980946)
Target
GTPase NRas (NRAS)
Spezies
Human
Quelle
Synthetic
Applikation
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- Middle Region
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Sequenz
- ADINLYREQI KRVKDSDDVP MVLVGNKCDL PTRTVDTKQA HELAKSYGIP
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Produktmerkmale
- This is a synthetic peptide designed for use in combination with anti-NRAS Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Aufreinigung
- Purified
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Applikationshinweise
- Each Investigator should determine their own optimal working dilution for specific applications.
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Lyophilized
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Rekonstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Konzentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handhabung
- Avoid repeated freeze-thaw cycles.
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Lagerung
- -20 °C
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Informationen zur Lagerung
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- GTPase NRas (NRAS)
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Hintergrund
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This is an N-ras oncogene encoding a membrane protein that shuttles between the Golgi apparatus and the plasma membrane. This shuttling is regulated through palmitoylation and depalmitoylation by the ZDHHC9-GOLGA7 complex. The encoded protein, which has intrinsic GTPase activity, is activated by a guanine nucleotide-exchange factor and inactivated by a GTPase activating protein. Mutations in this gene have been associated with somatic rectal cancer, follicular thyroid cancer, autoimmune lymphoproliferative syndrome, Noonan syndrome, and juvenile myelomonocytic leukemia.
Alias Symbols: ALPS4, N-ras, NRAS1, NS6
Protein Interaction Partner: RAF1,ACVR1,ARHGAP4,BCL2,PIK3CA,PLCE1,RACGAP1,RAF1,RAP1GDS1,RASGRP2,RASSF5,SHOC2,SMAD4,SMURF2,MLLT4,PIK3CG,PLCE1,RAF1,RAP1GDS1
Protein Size: 189 -
Molekulargewicht
- 21 kDa
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Gen-ID
- 4893
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NCBI Accession
- NM_002524, NP_002515
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UniProt
- P01111
Target
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