GTPase NRas (NRAS) (Middle Region) Peptid
NRAS
Reaktivität: Human
Wirt: Synthetic
BP, WB
-
- Target Alle GTPase NRas (NRAS) Produkte
- GTPase NRas (NRAS)
- Protein Region
- Middle Region
- Spezies
- Human
-
Quelle
- Synthetic
- Applikation
- Blocking Peptide (BP), Western Blotting (WB)
- Sequenz
- ADINLYREQI KRVKDSDDVP MVLVGNKCDL PTRTVDTKQA HELAKSYGIP
- Produktmerkmale
- This is a synthetic peptide designed for use in combination with anti-NRAS Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Aufreinigung
- Purified
-
-
- Applikationshinweise
- Each Investigator should determine their own optimal working dilution for specific applications.
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
-
- Format
- Lyophilized
- Rekonstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Konzentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handhabung
- Avoid repeated freeze-thaw cycles.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
-
- Target
- GTPase NRas (NRAS)
- Hintergrund
-
This is an N-ras oncogene encoding a membrane protein that shuttles between the Golgi apparatus and the plasma membrane. This shuttling is regulated through palmitoylation and depalmitoylation by the ZDHHC9-GOLGA7 complex. The encoded protein, which has intrinsic GTPase activity, is activated by a guanine nucleotide-exchange factor and inactivated by a GTPase activating protein. Mutations in this gene have been associated with somatic rectal cancer, follicular thyroid cancer, autoimmune lymphoproliferative syndrome, Noonan syndrome, and juvenile myelomonocytic leukemia.
Alias Symbols: ALPS4, N-ras, NRAS1, NS6
Protein Interaction Partner: RAF1,ACVR1,ARHGAP4,BCL2,PIK3CA,PLCE1,RACGAP1,RAF1,RAP1GDS1,RASGRP2,RASSF5,SHOC2,SMAD4,SMURF2,MLLT4,PIK3CG,PLCE1,RAF1,RAP1GDS1
Protein Size: 189 - Molekulargewicht
- 21 kDa
- Gen-ID
- 4893
- NCBI Accession
- NM_002524, NP_002515
- UniProt
- P01111
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