Neutrophil Cytosolic Factor 4, 40kDa (NCF4) (C-Term) Peptid
NCF4
Reaktivität: Human
Wirt: Synthetic
BP, WB
Produktnummer ABIN980524
Kurzübersicht für Neutrophil Cytosolic Factor 4, 40kDa (NCF4) (C-Term) Peptid (ABIN980524)
Target
NCF4
(Neutrophil Cytosolic Factor 4, 40kDa (NCF4))
Spezies
Human
Quelle
Synthetic
Applikation
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- C-Term
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Sequenz
- PSLRPLPLTS PSHGSLSHSK APSGSQMSHN AVTSHQRPGW PGQPHSPFPH
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Produktmerkmale
- This is a synthetic peptide designed for use in combination with anti-NCF4 Antibody(ARP58922_P050),. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Aufreinigung
- Purified
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Applikationshinweise
- Each Investigator should determine their own optimal working dilution for specific applications.
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Lyophilized
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Rekonstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Konzentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handhabung
- Avoid repeated freeze-thaw cycles.
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Lagerung
- -20 °C
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Informationen zur Lagerung
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- NCF4 (Neutrophil Cytosolic Factor 4, 40kDa (NCF4))
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Hintergrund
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NCF4 is a cytosolic regulatory component of the superoxide-producing phagocyte NADPH-oxidase, a multicomponent enzyme system important for host defense. It interacts primarily with neutrophil cytosolic factor 2 (NCF2/p67-phox) to form a complex with neutrophil cytosolic factor 1 (NCF1/p47-phox), which further interacts with the small G protein RAC1 and translocates to the membrane upon cell stimulation. This complex then activates flavocytochrome b, the membrane-integrated catalytic core of the enzyme system. The PX domain of this protein can bind phospholipid products of the PI(3) kinase, which suggests its role in PI(3) kinase-mediated signaling events. The phosphorylation of this protein was found to negatively regulate the enzyme activity. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
Alias Symbols: MGC3810, NCF, P40PHOX, SH3PXD4
Protein Interaction Partner: CORO1A,CYBA,CYBB,MSN,NCF1,NCF2,PRKCD,TXN,XRCC6,MSN,NCF1,NCF2,PRKDC,TXN,XRCC6
Protein Size: 348 -
Molekulargewicht
- 39 kDa
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Gen-ID
- 4689
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NCBI Accession
- NM_013416, NP_038202
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UniProt
- A8K4F9
Target
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