MRE11 Meiotic Recombination 11 Homolog A (S. Cerevisiae) (MRE11A) (Middle Region) Peptid
MRE11A
Reaktivität: Human
Wirt: Synthetic
BP, WB
Produktnummer ABIN980226
Kurzübersicht für MRE11 Meiotic Recombination 11 Homolog A (S. Cerevisiae) (MRE11A) (Middle Region) Peptid (ABIN980226)
Target
Mre11 (MRE11A)
(MRE11 Meiotic Recombination 11 Homolog A (S. Cerevisiae) (MRE11A))
Spezies
Human
Quelle
Synthetic
Applikation
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- Middle Region
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Sequenz
- RFRETRQKNT NEEDDEVREA MTRARALRSQ SEESASAFSA DDLMSIDLAE
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Produktmerkmale
- This is a synthetic peptide designed for use in combination with anti-MRE11A Antibody(ARP56645_P050),. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Aufreinigung
- Purified
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Applikationshinweise
- Each Investigator should determine their own optimal working dilution for specific applications.
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Lyophilized
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Rekonstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Konzentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handhabung
- Avoid repeated freeze-thaw cycles.
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Lagerung
- -20 °C
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Informationen zur Lagerung
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Mre11 (MRE11A) (MRE11 Meiotic Recombination 11 Homolog A (S. Cerevisiae) (MRE11A))
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Hintergrund
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This gene encodes a nuclear protein involved in homologous recombination, telomere length maintenance, and DNA double-strand break repair. By itself, the protein has 3' to 5' exonuclease activity and endonuclease activity. The protein forms a complex with the RAD50 homolog, this complex is required for nonhomologous joining of DNA ends and possesses increased single-stranded DNA endonuclease and 3' to 5' exonuclease activities. In conjunction with a DNA ligase, this protein promotes the joining of noncomplementary ends in vitro using short homologies near the ends of the DNA fragments. This gene has a pseudogene on chromosome 3. Alternative splicing of this gene results in two transcript variants encoding different isoforms.
Alias Symbols: ATLD, HNGS1, MRE11, MRE11B
Protein Interaction Partner: NBN,NEK1,RAD50,ATM,CCNE1,DCLRE1C,EP300,FANCD2,H2AFX,LIG1,NBN,NEK1,RAD50,XRCC6,ATM,ATM,ATR,BLM,BRCA1,LIG1,MDC1,MLH1,MSH2,MSH6,NBN,NBN,PRKDC,RAD50,RECQL5,RFC1,TERF2,TERF2IP,TP53,USP11,XRCC6
Protein Size: 708 -
Molekulargewicht
- 80 kDa
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Gen-ID
- 4361
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NCBI Accession
- NM_005591, NP_005582
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UniProt
- P49959
Target
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