Microphthalmia-Associated Transcription Factor (MITF) (Middle Region) Peptid
MITF
Reaktivität: Human
Wirt: Synthetic
BP, WB
Produktnummer ABIN980098
Kurzübersicht für Microphthalmia-Associated Transcription Factor (MITF) (Middle Region) Peptid (ABIN980098)
Target
MITF
(Microphthalmia-Associated Transcription Factor (MITF))
Spezies
Human
Quelle
Synthetic
Applikation
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- Middle Region
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Produktmerkmale
- This is a synthetic peptide designed for use in combination with anti-MITF antibody (Catalog #: ARP37978_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Aufreinigung
- Purified
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Applikationshinweise
- Each Investigator should determine their own optimal working dilution for specific applications.
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Lyophilized
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Rekonstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Konzentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handhabung
- Avoid repeated freeze-thaw cycles.
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Lagerung
- -20 °C
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Informationen zur Lagerung
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- MITF (Microphthalmia-Associated Transcription Factor (MITF))
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Hintergrund
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MITF is a transcription factor that contains both basic helix-loop-helix and leucine zipper structural features. It regulates the differentiation and development of melanocytes retinal pigment epithelium and is also responsible for pigment cell-specific transcription of the melanogenesis enzyme genes. Heterozygous mutations in the this gene cause auditory-pigmentary syndromes, such as Waardenburg syndrome type 2 and Tietz syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified. This gene encodes a transcription factor that contains both basic helix-loop-helix and leucine zipper structural features. It regulates the differentiation and development of melanocytes retinal pigment epithelium and is also responsible for pigment cell-specific transcription of the melanogenesis enzyme genes. Heterozygous mutations in the this gene cause auditory-pigmentary syndromes, such as Waardenburg syndrome type 2 and Tietz syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified.
Alias Symbols: WS2A, MI, WS2, bHLHe32
Protein Interaction Partner: CTNNB1,EP300,FOS,GSK3B,LEF1,MAPK1,MAPK14,OTX2,PATZ1,PAX3,PAX6,PIAS3,RPS6KA1,SPI1,SUMO1,TFE3,TFEB,TFEC,UBE2I,CDK2,CDKN1A,FOS,LEF1,PATZ1,PAX6,PIAS3,RB1,SPI1,TFE3,TFEC,UBE2I
Protein Size: 419 -
Molekulargewicht
- 47 kDa
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Gen-ID
- 4286
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NCBI Accession
- NM_000248, NP_000239
Target
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