Blocking Peptide (BP), Western Blotting (WB), Immunohistochemistry (IHC)
Produktmerkmale
This is a synthetic peptide designed for use in combination with anti-MCM7 antibody (Catalog #: ARP36652_T100). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
MCM7 encodes a protein that is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 6 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme.The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 6 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. Cyclin D1-dependent kinase, CDK4, is found to associate with this protein, and may regulate the binding of this protein with the tumorsuppressor protein RB1/RB. Alternatively spliced transcript variants encoding distinct isoforms have been reported.
Alias Symbols: MCM2, CDC47, P85MCM, P1CDC47, PNAS146, P1.1-MCM3
Protein Interaction Partner: RB1,RBL1,RBL2,MCM3,MCM4,MCM7,ATRIP,CCNH,CDC45,CDC6,CDC7,CDK7,CDKN1B,CRLS1,DBF4,FHL2,HIST3H3,MBIP,MCM10,MCM2,MCM3,MCM4,MCM5,MCM6,MCM7,MCM8,MNAT1,NFKBIA,ORC1L,ORC2L,ORC3L,ORC4L,ORC5L,ORC6L,PLK1,RAD17,RB1,RBL1,RBL2,RBM8A,RPA1,SMC1A,UBE3A,ATR,ATRIP,CCNH,CDC45,CDC6,CDC7,CDK7,CDT1,CNOT8,DBF4,FHL2,GIPC1,GSTK1,MBIP,MCM10,MCM2,MCM3,MCM3,MCM4,MCM4,MCM5,MCM6,MCM7,MCM8,MNAT1,MYC,NEK6,ORC1L,ORC2L,ORC3L,ORC5L,PELO,RB1,RBL1,RBL2,RBM8A,RECQL5,RPA1,TH1L,TRAF6,UBE3A