Minichromosome Maintenance Deficient 10 (MCM10) (Middle Region) Peptid
MCM10
Reaktivität: Human
Wirt: Synthetic
BP, WB
Produktnummer ABIN979890
Kurzübersicht für Minichromosome Maintenance Deficient 10 (MCM10) (Middle Region) Peptid (ABIN979890)
Target
MCM10
(Minichromosome Maintenance Deficient 10 (MCM10))
Spezies
Human
Quelle
Synthetic
Applikation
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- Middle Region
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Produktmerkmale
- This is a synthetic peptide designed for use in combination with anti-MCM10 antibody (Catalog #: ARP36656_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Aufreinigung
- Purified
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Applikationshinweise
- Each Investigator should determine their own optimal working dilution for specific applications.
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Lyophilized
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Rekonstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Konzentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handhabung
- Avoid repeated freeze-thaw cycles.
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Lagerung
- -20 °C
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Informationen zur Lagerung
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- MCM10 (Minichromosome Maintenance Deficient 10 (MCM10))
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Hintergrund
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This protein is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre-RC) and it may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein can interact with MCM2 and MCM6, as well as with the origin recognition protein ORC2. It is regulated by proteolysis and phosphorylation in a cell cycle-dependent manner. Studies of a similar protein in Xenopus suggest that the chromatin binding of this protein at the onset of DNA replication is after pre-RC assembly and before origin unwinding.The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre-RC) and it may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein can interact with MCM2 and MCM6, as well as with the origin recognition protein ORC2. It is regulated by proteolysis and phosphorylation in a cell cycle-dependent manner. Studies of a similar protein in Xenopus suggest that the chromatin binding of this protein at the onset of DNA replication is after pre-RC assembly and before origin unwinding. Alternatively spliced transcript variants encoding distinct isoforms have been identified.
Alias Symbols: CNA43, MGC126776, PRO2249, DNA43
Protein Interaction Partner: CALCOCO2,CCDC85B,CCND1,CCND3,CDC45,CDC5L,CDC6,CDC7,CDK6,CDKN1A,CDKN2A,CEP70,CEP72,DPPA2,HAUS1,HOOK2,KRT15,MCM2,MCM3,MCM4,MCM6,MCM7,NINL,ORC2L,ORC3L,ORC4L,TRIM37,ZBTB43,ZBTB8B,CALCOCO2,CCDC85B,CCND3,CEP70,CEP72,DPPA2,HOOK2,KRT15,LMNB1,MCM6,MCM7,Mcm2,Mcm6,NINL,ORC2L,RPAP1,TRIM37,ZBTB43,ZBTB8A
Protein Size: 874 -
Molekulargewicht
- 98 kDa
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Gen-ID
- 55388
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NCBI Accession
- NM_018518, NP_060988
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UniProt
- B7ZKZ8
Target
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