Mitogen-Activated Protein Kinase Kinase 3 (MAP2K3) Peptid
MAP2K3
Reaktivität: Human
Wirt: Synthetic
BP, IHC, WB
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- Target Alle MAP2K3 Produkte
- MAP2K3 (Mitogen-Activated Protein Kinase Kinase 3 (MAP2K3))
- Spezies
- Human
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Quelle
- Synthetic
- Applikation
- Blocking Peptide (BP), Immunohistochemistry (IHC), Western Blotting (WB)
- Produktmerkmale
- This is a synthetic peptide designed for use in combination with anti-MAP2K3 antibody (Catalog #: ARP42064_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Aufreinigung
- Purified
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- Applikationshinweise
- Each Investigator should determine their own optimal working dilution for specific applications.
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Lyophilized
- Rekonstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Konzentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handhabung
- Avoid repeated freeze-thaw cycles.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- MAP2K3 (Mitogen-Activated Protein Kinase Kinase 3 (MAP2K3))
- Hintergrund
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MAP2K3 is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is activated by mitogenic and environmental stress, and participates in the MAP kinase-mediated signaling cascade. It phosphorylates and thus activates MAPK14/p38-MAPK. This kinase can be activated by insulin, and is necessary for the expression of glucose transporter. Expression of RAS oncogene is found to result in the accumulation of the active form of this kinase, which thus leads to the constitutive activation of MAPK14, and confers oncogenic transformation of primary cells. The inhibition of this kinase is involved in the pathogenesis of Yersina pseudotuberculosis. The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is activated by mitogenic and environmental stress, and participates in the MAP kinase-mediated signaling cascade. It phosphorylates and thus activates MAPK14/p38-MAPK. This kinase can be activated by insulin, and is necessary for the expression of glucose transporter. Expression of RAS oncogene is found to result in the accumulation of the active form of this kinase, which thus leads to the constitutive activation of MAPK14, and confers oncogenic transformation of primary cells. The inhibition of this kinase is involved in the pathogenesis of Yersina pseudotuberculosis. Multiple alternatively spliced transcript variants that encode distinct isoforms have been reported for this gene.
Alias Symbols: MAPKK3, MEK3, MKK3, PRKMK3, SAPKK2, SAPKK-2
Protein Interaction Partner: MAPK14,MAP3K4,DCTN1,DYRK1B,ELK1,MAP3K4,MAPK12,MAPK14,MAPK3,MAPK8IP2,PLCB2,SMAD7,TAOK1,TAOK2,MAP2K6,MAP3K4,MAPK14,MAPK3,MAPK8IP2,Mapk14,NPHS1,PLCB2,SMAD7,TAOK2
Protein Size: 318 - Molekulargewicht
- 36 kDa
- Gen-ID
- 5606
- NCBI Accession
- NM_002756, NP_002747
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