Low Density Lipoprotein Receptor Adaptor Protein 1 (LDLRAP1) (N-Term) Peptid
LDLRAP1
Reaktivität: Human
Wirt: Synthetic
BP, WB
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- Target Alle LDLRAP1 Produkte
- LDLRAP1 (Low Density Lipoprotein Receptor Adaptor Protein 1 (LDLRAP1))
- Protein Region
- N-Term
- Spezies
- Human
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Quelle
- Synthetic
- Applikation
- Blocking Peptide (BP), Western Blotting (WB)
- Produktmerkmale
- This is a synthetic peptide designed for use in combination with anti-LDLRAP1 antibody (Catalog #: ARP55308_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Aufreinigung
- Purified
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- Applikationshinweise
- Each Investigator should determine their own optimal working dilution for specific applications.
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Lyophilized
- Rekonstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Konzentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handhabung
- Avoid repeated freeze-thaw cycles.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- LDLRAP1 (Low Density Lipoprotein Receptor Adaptor Protein 1 (LDLRAP1))
- Synonyme
- ARH Peptide, ARH1 Peptide, ARH2 Peptide, FHCB1 Peptide, FHCB2 Peptide, AA691260 Peptide, Arh Peptide, Arh1 Peptide, RGD1563417 Peptide, arh Peptide, arh1 Peptide, arh2 Peptide, fhcb1 Peptide, fhcb2 Peptide, xptb Peptide, LDLRAP1 Peptide, ldlrap1 Peptide, sb:cb50 Peptide, zgc:56121 Peptide, zgc:158745 Peptide, low density lipoprotein receptor adaptor protein 1 Peptide, low density lipoprotein receptor adaptor protein 1 L homeolog Peptide, low density lipoprotein receptor adaptor protein 1 S homeolog Peptide, low density lipoprotein receptor adaptor protein 1a Peptide, low density lipoprotein receptor adaptor protein 1b Peptide, LDLRAP1 Peptide, Ldlrap1 Peptide, ldlrap1 Peptide, ldlrap1.L Peptide, ldlrap1.S Peptide, ldlrap1a Peptide, ldlrap1b Peptide
- Hintergrund
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LDLRAP1 is an adapter protein (clathrin-associated sorting protein (CLASP)) required for efficient endocytosis of the LDL receptor (LDLR) in polarized cells such as hepatocytes and lymphocytes, but not in non-polarized cells (fibroblasts). LDLRAP1 may be required for LDL binding and internalization but not for receptor clustering in coated pits. LDLRAP1 may facilitate the endocytocis of LDLR and LDLR-LDL complexes from coated pits by stabilizing the interaction between the receptor and the structural components of the pits. LDLRAP1 may also be involved in the internalization of other LDLR family members. LDLRAP1 binds to phosphoinositides, which regulate clathrin bud assembly at the cell surface.The protein encoded by this gene is a cytosolic protein which contains a phosphotyrosine binding (PTD) domain. The PTD domain has been found to interact with the cytoplasmic tail of the LDL receptor. Mutations in this gene lead to LDL receptor malfunction and cause the disorder autosomal recessive hypercholesterolaemia. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: ARH, ARH1, ARH2, DKFZp586D0624, FHCB1, FHCB2, MGC34705
Protein Interaction Partner: AP2B1,APP,CLTC,LDLR,LRP2,TFAP2A,AP2B1,CLTC,LDLR,LRP2
Protein Size: 308 - Molekulargewicht
- 34 kDa
- Gen-ID
- 26119
- NCBI Accession
- NM_015627, NP_056442
- UniProt
- Q5SW96
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