Kelch-Like ECH-Associated Protein 1 (KEAP1) Peptid
KEAP1
Reaktivität: Human
Wirt: Synthetic
BP, IHC, WB
Produktnummer ABIN978875
Kurzübersicht für Kelch-Like ECH-Associated Protein 1 (KEAP1) Peptid (ABIN978875)
Target
KEAP1
(Kelch-Like ECH-Associated Protein 1 (KEAP1))
Spezies
Human
Quelle
Synthetic
Applikation
Blocking Peptide (BP), Immunohistochemistry (IHC), Western Blotting (WB)
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Produktmerkmale
- This is a synthetic peptide designed for use in combination with anti-KEAP1 antibody (Catalog #: ARP34728_T100). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Aufreinigung
- Purified
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Applikationshinweise
- Each Investigator should determine their own optimal working dilution for specific applications.
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Lyophilized
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Rekonstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Konzentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handhabung
- Avoid repeated freeze-thaw cycles.
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Lagerung
- -20 °C
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Informationen zur Lagerung
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- KEAP1 (Kelch-Like ECH-Associated Protein 1 (KEAP1))
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Hintergrund
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KEAP1 contains KELCH-1 like domains, as well as a BTB/POZ domain. Kelch-like ECH-associated protein 1 interacts with NF-E2-related factor 2 in a redox-sensitive manner and the dissociation of the proteins in the cytoplasm is followed by transportation of NF-E2-related factor 2 to the nucleus. This interaction results in the expression of the catalytic subunit of gamma-glutamylcysteine synthetase.This gene encodes a protein containing KELCH-1 like domains, as well as a BTB/POZ domain. Kelch-like ECH-associated protein 1 interacts with NF-E2-related factor 2 in a redox-sensitive manner and the dissociation of the proteins in the cytoplasm is followed by transportation of NF-E2-related factor 2 to the nucleus. This interaction results in the expression of the catalytic subunit of gamma-glutamylcysteine synthetase. Two alternatively spliced transcript variants encoding the same isoform have been found for this gene.
Alias Symbols: INrf2, KIAA0132, KLHL19, MGC10630, MGC1114, MGC20887, MGC4407, MGC9454
Protein Interaction Partner: BPTF,ETF1,FAM46A,MYO7A,NFE2L2,ARCN1,BBS1,BTRC,C10orf119,COPG,CUL3,ETF1,FAM123B,FAM129B,GABPA,GBAS,GET4,KIAA0564,MAD2L1,MAZ,MYO7A,NFE2L2,OSBPL10,PFAS,PGAM5,RBM45,SASS6,SLK,SQSTM1,TMEM160,TSC22D4,UBC,USP11,ZRANB1
Protein Size: 624 -
Molekulargewicht
- 70 kDa
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Gen-ID
- 9817
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NCBI Accession
- NM_203500, NP_987096
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UniProt
- Q14145
Target
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