Janus Kinase 3 (JAK3) (Middle Region) Peptid
JAK3
Reaktivität: Human
Wirt: Synthetic
BP, WB
Produktnummer ABIN978683
Kurzübersicht für Janus Kinase 3 (JAK3) (Middle Region) Peptid (ABIN978683)
Target
JAK3
(Janus Kinase 3 (JAK3))
Spezies
Human
Quelle
Synthetic
Applikation
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- Middle Region
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Produktmerkmale
- This is a synthetic peptide designed for use in combination with anti-JAK3 antibody (Catalog #: ARP54306_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Aufreinigung
- Purified
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Applikationshinweise
- Each Investigator should determine their own optimal working dilution for specific applications.
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Lyophilized
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Rekonstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Konzentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handhabung
- Avoid repeated freeze-thaw cycles.
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Lagerung
- -20 °C
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Informationen zur Lagerung
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- JAK3 (Janus Kinase 3 (JAK3))
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Hintergrund
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JAK3 is a member of the Janus kinase (JAK) family of tyrosine kinases, which is involved in cytokine receptor-mediated intracellular signal transduction. JAK3 is predominantly expressed in immune cells and transduces a signal in response to its activation via tyrosine phosphorylation by interleukin receptors. Mutations in JAK3 are associated with autosomal SCID (severe combined immunodeficiency disease).The protein encoded by this gene is a member of the Janus kinase (JAK) family of tyrosine kinases involved in cytokine receptor-mediated intracellular signal transduction. It is predominantly expressed in immune cells and transduces a signal in response to its activation via tyrosine phosphorylation by interleukin receptors. Mutations in this gene are associated with autosomal SCID (severe combined immunodeficiency disease). Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript was available for the full length of the gene. The extent of this transcript is supported by transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: JAK-3, JAK3_HUMAN, JAKL, L-JAK, LJAK
Protein Interaction Partner: JAK3,JAK3,ALK,CD247,CD40,CXCR4,FES,IL2RB,IL2RG,IL4R,IL7R,INPP5D,IRS1,IRS2,JAK1,JAK2,JAK3,KHDRBS1,LCK,PIK3R1,PRMT5,PTK2B,PTPN2,PTPN6,PTPRC,SH2B2,SHB,SOCS1,SOCS3,STAM,STAM2,STAT3,STAT5A,TIAF1,VIL1,ALK,CD247,CD3E,CXCR4,IL2RG,IRS1,LEPR,PRMT5,PTK2B,SHB,STAM,STAM2,STAT5A,STAT5B,TIAF1
Protein Size: 1124 -
Molekulargewicht
- 125 kDa
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Gen-ID
- 3718
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NCBI Accession
- NM_000215, NP_000206
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UniProt
- P52333
Target
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