Inhibitor of Growth Family, Member 3 (ING3) (Middle Region) Peptid
ING3
Reaktivität: Human, Maus
Wirt: Synthetic
BP, IHC, WB
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- Target Alle ING3 Produkte
- ING3 (Inhibitor of Growth Family, Member 3 (ING3))
- Protein Region
- Middle Region
- Spezies
- Human, Maus
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Quelle
- Synthetic
- Applikation
- Blocking Peptide (BP), Immunohistochemistry (IHC), Western Blotting (WB)
- Produktmerkmale
- This is a synthetic peptide designed for use in combination with anti-ING3 antibody (Catalog #: ARP33347_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Aufreinigung
- Purified
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- Applikationshinweise
- Each Investigator should determine their own optimal working dilution for specific applications.
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Lyophilized
- Rekonstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Konzentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handhabung
- Avoid repeated freeze-thaw cycles.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- ING3 (Inhibitor of Growth Family, Member 3 (ING3))
- Hintergrund
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ING3 is similar to ING1, a tumor suppressor protein that can interact with TP53, inhibit cell growth, and induce apoptosis. This protein contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. This gene can activate p53 trans-activated promoters, including promoters of p21/waf1 and bax. Overexpression of this gene has been shown to inhibit cell growth and induce apoptosis. Allelic loss and reduced expression of this gene were detected in head and neck cancers.The protein encoded by this gene is similar to ING1, a tumor suppressor protein that can interact with TP53, inhibit cell growth, and induce apoptosis. This protein contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. This gene can activate p53 trans-activated promoters, including promoters of p21/waf1 and bax. Overexpression of this gene has been shown to inhibit cell growth and induce apoptosis. Allelic loss and reduced expression of this gene were detected in head and neck cancers. Two alternatively spliced transcript variants encoding different isoforms have been observed.
Alias Symbols: Eaf4, FLJ20089, ING2, p47ING3, MEAF4
Protein Interaction Partner: NR1H2,NR1H3,ACTL6A,BRD8,DMAP1,EPC1,EPC2,HHT1,HHT2,KAT5,MEAF6,MORF4L1,RUVBL1,RUVBL2,TRRAP,YEATS4
Protein Size: 418 - Molekulargewicht
- 47 kDa
- Gen-ID
- 54556
- NCBI Accession
- NM_019071, NP_061944
- UniProt
- Q9NXR8
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