Insulin-Degrading Enzyme (IDE) (N-Term) Peptid
IDE
Reaktivität: Human
Wirt: Synthetic
BP, WB
Produktnummer ABIN978389
Kurzübersicht für Insulin-Degrading Enzyme (IDE) (N-Term) Peptid (ABIN978389)
Target
IDE
(Insulin-Degrading Enzyme (IDE))
Spezies
Human
Quelle
Synthetic
Applikation
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- N-Term
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Sequenz
- LDVHIGSLSD PPNIAGLSHF CEHMLFLGTK KYPKENEYSQ FLSEHAGSSN
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Produktmerkmale
- This is a synthetic peptide designed for use in combination with anti-IDE Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Aufreinigung
- Purified
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Applikationshinweise
- Each Investigator should determine their own optimal working dilution for specific applications.
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Lyophilized
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Rekonstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Konzentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handhabung
- Avoid repeated freeze-thaw cycles.
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Lagerung
- -20 °C
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Informationen zur Lagerung
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- IDE (Insulin-Degrading Enzyme (IDE))
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Hintergrund
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This gene encodes a zinc metallopeptidase that degrades intracellular insulin, and thereby terminates insulins activity, as well as participating in intercellular peptide signalling by degrading diverse peptides such as glucagon, amylin, bradykinin, and kallidin. The preferential affinity of this enzyme for insulin results in insulin-mediated inhibition of the degradation of other peptides such as beta-amyloid. Deficiencies in this protein's function are associated with Alzheimer's disease and type 2 diabetes mellitus but mutations in this gene have not been shown to be causitive for these diseases. This protein localizes primarily to the cytoplasm but in some cell types localizes to the extracellular space, cell membrane, peroxisome, and mitochondrion.
Alias Symbols: FLJ35968, INSULYSIN
Protein Interaction Partner: APP,AR,IGF1,IGF2,INS,NR3C1,IGF1,IGF2,ZHX2
Protein Size: 1019 -
Molekulargewicht
- 118 kDa
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Gen-ID
- 3416
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NCBI Accession
- NM_004969, NP_004960
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UniProt
- P14735
Target
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