HLA Class I alpha F (HLAF) Peptid
HLAF
Reaktivität: Human
Wirt: Synthetic
BP, WB, IHC
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- Target Alle HLA-F (HLAF) Produkte
- HLA-F (HLAF) (HLA Class I alpha F (HLAF))
- Spezies
- Human
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Quelle
- Synthetic
- Applikation
- Blocking Peptide (BP), Western Blotting (WB), Immunohistochemistry (IHC)
- Produktmerkmale
- This is a synthetic peptide designed for use in combination with anti-HLA-F antibody (Catalog #: ARP49411_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Aufreinigung
- Purified
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- Applikationshinweise
- Each Investigator should determine their own optimal working dilution for specific applications.
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Lyophilized
- Rekonstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Konzentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handhabung
- Avoid repeated freeze-thaw cycles.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- HLA-F (HLAF) (HLA Class I alpha F (HLAF))
- Hintergrund
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HLA-F belongs to the HLA class I heavy chain paralogues. It is a non-classical heavy chain that forms a heterodimer with a beta-2 microglobulin light chain, with the heavy chain anchored in the membrane. Unlike most other HLA heavy chains, this molecule is localized in the endoplasmic reticulum and Golgi apparatus, with a small amount present at the cell surface in some cell types. It contains a divergent peptide-binding groove, and is thought to bind a restricted subset of peptides for immune presentation. This gene belongs to the HLA class I heavy chain paralogues. It encodes a non-classical heavy chain that forms a heterodimer with a beta-2 microglobulin light chain, with the heavy chain anchored in the membrane. Unlike most other HLA heavy chains, this molecule is localized in the endoplasmic reticulum and Golgi apparatus, with a small amount present at the cell surface in some cell types. It contains a divergent peptide-binding groove, and is thought to bind a restricted subset of peptides for immune presentation. This gene exhibits few polymorphisms. Multiple transcript variants encoding different isoforms have been found for this gene. These variants lack a coding exon found in transcripts from other HLA paralogues due to an altered splice acceptor site, resulting in a shorter cytoplasmic domain.
Alias Symbols: CDA12, HLA-5.4, HLA-CDA12, HLAF
Protein Interaction Partner: B2M,HLA-F,LILRB1,LILRB2,TAP1,LILRB1,LILRB2
Protein Size: 442 - Molekulargewicht
- 48 kDa
- Gen-ID
- 3134
- NCBI Accession
- NM_001098479, NP_001091949
- UniProt
- P30511
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