Histone Deacetylase 9 (HDAC9) (Middle Region) Peptid
HDAC9
Reaktivität: Human
Wirt: Synthetic
BP, WB
Produktnummer ABIN977914
Kurzübersicht für Histone Deacetylase 9 (HDAC9) (Middle Region) Peptid (ABIN977914)
Target
HDAC9
(Histone Deacetylase 9 (HDAC9))
Spezies
Human
Quelle
Synthetic
Applikation
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- Middle Region
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Produktmerkmale
- This is a synthetic peptide designed for use in combination with anti-HDAC9 antibody (Catalog #: ARP42793_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Aufreinigung
- Purified
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Applikationshinweise
- Each Investigator should determine their own optimal working dilution for specific applications.
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Lyophilized
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Rekonstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Konzentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handhabung
- Avoid repeated freeze-thaw cycles.
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Lagerung
- -20 °C
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Informationen zur Lagerung
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- HDAC9 (Histone Deacetylase 9 (HDAC9))
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Hintergrund
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Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. HDAC9 has sequence homology to members of the histone deacetylase family. The MITR protein lacks the histone deacetylase catalytic domain. It represses MEF2 activity through recruitment of multicomponent corepressor complexes that include CtBP and HDACs. HDAC9 may play a role in hematopoiesis. Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene has sequence homology to members of the histone deacetylase family. This gene is orthologous to the Xenopus and mouse MITR genes. The MITR protein lacks the histone deacetylase catalytic domain. It represses MEF2 activity through recruitment of multicomponent corepressor complexes that include CtBP and HDACs. This encoded protein may play a role in hematopoiesis. Multiple alternatively spliced transcripts have been described for this gene but the full-length nature of some of them has not been determined.
Alias Symbols: DKFZp779K1053, HD7, HDAC, HDAC7, HDAC7B, HDAC9B, HDAC9FL, HDRP, KIAA0744, MITR, HD9, HD7b
Protein Interaction Partner: BCL6,CBX5,CTBP1,ETV6,HDAC1,HDAC3,HDAC4,MEF2A,NCOR1,SIN3A,SIN3B,SUMO1,SUMO2,ZBTB16,CBX5,CTBP1,ETV6,FOXP3,HDAC1,HDAC1,HDAC3,HDAC3,HDAC4,HEY2,HIST2H3A,HIST4H4,MEF2A,MORF4L2,NCOR1,NRIP1,SIN3A,SIN3B,SUV39H1
Protein Size: 590 -
Molekulargewicht
- 66 kDa
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Gen-ID
- 9734
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NCBI Accession
- NM_014707, NP_055522
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UniProt
- A7E2F3
Target
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