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Hepatitis A Virus Cellular Receptor 2 (TIM 3) (N-Term) Peptid

TIM 3 Reaktivität: Human Wirt: Synthetic BP, WB
Produktnummer ABIN977863
  • Target Alle TIM3 (TIM 3) Produkte
    TIM3 (TIM 3) (Hepatitis A Virus Cellular Receptor 2 (TIM 3))
    Protein Region
    N-Term
    Spezies
    Human
    Quelle
    • 6
    Synthetic
    Applikation
    Blocking Peptide (BP), Western Blotting (WB)
    Produktmerkmale
    This is a synthetic peptide designed for use in combination with anti-HAVCR2 antibody (Catalog #: ARP45550_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
    Aufreinigung
    Purified
  • Applikationshinweise
    Each Investigator should determine their own optimal working dilution for specific applications.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Rekonstitution
    Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
    Konzentration
    1 mg/mL
    Buffer
    Final peptide concentration is 1 mg/mL in PBS.
    Handhabung
    Avoid repeated freeze-thaw cycles.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
  • Target
    TIM3 (TIM 3) (Hepatitis A Virus Cellular Receptor 2 (TIM 3))
    Substanzklasse
    Virus
    Hintergrund
    HAVCR2 regulates macrophage activation. HAVCR2 inhibits T-helper type 1 lymphocyte (Th1)-mediated auto- and alloimmune responses and promotes immunological tolerance. HAVCR2 may be also involved in T-cell homing. HAVCR2 is the receptor for LGALS9.CD4 (MIM 186940)-positive T helper lymphocytes can be divided into types 1 (Th1) and 2 (Th2) on the basis of their cytokine secretion patterns. Th1 cells and their associated cytokines are involved in cell-mediated immunity to intracellular pathogens and delayed-type hypersensitivity reactions, whereas Th2 cells are involved in the control of extracellular helminthic infections and the promotion of atopic and allergic diseases. The 2 types of cells also cross-regulate the functions of the other. TIM3 is a Th1-specific cell surface protein that regulates macrophage activation and enhances the severity of experimental autoimmune encephalomyelitis in mice.[supplied by OMIM]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications. PRIMARYREFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-562 BC063431.1 1-562 563-1203 AF450243.1 476-1116 1204-2338 BC063431.1 1204-2338

    Alias Symbols: FLJ14428, KIM-3, TIM3, TIMD3, Tim-3, TIMD-3, HAVcr-2

    Protein Interaction Partner: HAVCR2

    Protein Size: 301
    Molekulargewicht
    33 kDa
    Gen-ID
    84868
    NCBI Accession
    NM_032782, NP_116171
    UniProt
    Q8TDQ0
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