This is a synthetic peptide designed for use in combination with anti-H2AFY2 Antibody(ARP57281_P050),. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
Each Investigator should determine their own optimal working dilution for specific applications.
Beschränkungen
Nur für Forschungszwecke einsetzbar
Format
Lyophilized
Rekonstitution
Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
Konzentration
1 mg/mL
Buffer
Final peptide concentration is 1 mg/mL in PBS.
Handhabung
Avoid repeated freeze-thaw cycles.
Lagerung
-20 °C
Informationen zur Lagerung
For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
Target
H2AFY2
(H2A Histone Family, Member Y2 (H2AFY2))
Synonyme
macroH2A2 Peptide, RGD1561371 Peptide, MGC69037 Peptide, MGC130768 Peptide, macroh2a2 Peptide, im:6898017 Peptide, wu:fa14g05 Peptide, zgc:114051 Peptide, H2AFY2 Peptide, H2A histone family member Y2 Peptide, H2A histone family, member Y2 Peptide, H2A histone family member Y2 L homeolog Peptide, core histone macro-H2A.2 Peptide, H2AFY2 Peptide, H2afy2 Peptide, h2afy2.L Peptide, h2afy2 Peptide, LOC100224559 Peptide, LOC100343925 Peptide, LOC100456998 Peptide, LOC489024 Peptide, LOC100738475 Peptide
Hintergrund
H2AFY2 is the variant histone H2A which replaces conventional H2A in a subset of nucleosomes where it represses transcription. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. H2AFY2 may be involved in stable X chromosome inactivation.