G protein beta subunit-like (GBL) (Middle Region) Peptid
GBL
Reaktivität: Human
Wirt: Synthetic
BP, WB
Kurzübersicht für G protein beta subunit-like (GBL) (Middle Region) Peptid (ABIN977310)
Target
GBL
(G protein beta subunit-like (GBL))
Spezies
Human
Quelle
Synthetic
Applikation
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- Middle Region
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Sequenz
- CAFSGDSQYI VTASSDNLAR LWCVETGEIK REYGGHQKAV VCLAFNDSVL
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Produktmerkmale
- This is a synthetic peptide designed for use in combination with anti-GBL Antibody(ARP57630_P050),. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Aufreinigung
- Purified
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Applikationshinweise
- Each Investigator should determine their own optimal working dilution for specific applications.
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Lyophilized
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Rekonstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Konzentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handhabung
- Avoid repeated freeze-thaw cycles.
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Lagerung
- -20 °C
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Informationen zur Lagerung
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- GBL (G protein beta subunit-like (GBL))
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Hintergrund
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GBL is the subunit of both mTORC1 and mTORC2, which regulate cell growth and survival in response to nutrient and hormonal signals. mTORC1 is activated in response to growth factors or amino-acids. Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'.
Alias Symbols: MGC111011, GBL, LST8, POP3, WAT1, GbetaL
Protein Interaction Partner: MTOR,RPTOR,RHEB,CCT2,KRT85,MTOR,RPTOR
Protein Size: 326 -
Molekulargewicht
- 36 kDa
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Gen-ID
- 64223
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NCBI Accession
- NM_022372, NP_071767
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UniProt
- Q9BVC4
Target
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