Fat Mass and Obesity-Associated (FTO) (N-Term) Peptid
FTO
Reaktivität: Maus
Wirt: Synthetic
BP, WB
Produktnummer ABIN977128
Kurzübersicht für Fat Mass and Obesity-Associated (FTO) (N-Term) Peptid (ABIN977128)
Target
FTO
(Fat Mass and Obesity-Associated (FTO))
Spezies
Maus
Quelle
Synthetic
Applikation
Blocking Peptide (BP), Western Blotting (WB)
-
-
Protein Region
- N-Term
-
Sequenz
- MKRVQTAEER EREAKKLRLL EELEDTWLPY LTPKDDEFYQ QWQLKYPKLV
-
Produktmerkmale
- This is a synthetic peptide designed for use in combination with anti-Fto Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
-
Aufreinigung
- Purified
-
-
-
-
Applikationshinweise
- Each Investigator should determine their own optimal working dilution for specific applications.
-
Beschränkungen
- Nur für Forschungszwecke einsetzbar
-
-
-
Format
- Lyophilized
-
Rekonstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
-
Konzentration
- 1 mg/mL
-
Buffer
- Final peptide concentration is 1 mg/mL in PBS.
-
Handhabung
- Avoid repeated freeze-thaw cycles.
-
Lagerung
- -20 °C
-
Informationen zur Lagerung
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
-
-
- FTO (Fat Mass and Obesity-Associated (FTO))
-
Hintergrund
-
Fto is a dioxygenase that repairs alkylated DNA and RNA by oxidative demethylation. Fto has highest activity towards single-stranded RNA containing 3-methyluracil, followed by single-stranded DNA containing 3-methylthymine. Fto has low demethylase activity towards single-stranded DNA containing 1-methyladenine or 3-methylcytosine. Fto has no activity towards 1-methylguanine and no detectable activity towards double-stranded DNA. Fto requires molecular oxygen, alpha-ketoglutarate and iron. Fto contributes to the regulation of the global metabolic rate, energy expenditure and energy homeostasis. Fto contributes to the regulation of body size and body fat accumulation.
Alias Symbols: AW743446, mKIAA1752
Protein Size: 502 -
Molekulargewicht
- 58 kDa
-
Gen-ID
- 26383
-
NCBI Accession
- NM_011936, NP_036066
-
UniProt
- Q8BGW1
Target
-
Sie sind hier:
