Telefon:: +49 (0)241 95 163 153
Fax:: +49 (0)241 95 163 155
E-Mail:: orders@antikoerper-online.de

Aktivieren Sie Javascript in Ihrem Browser, um unsere Webseite optimal zu nutzen.

F-Box Protein 31 (FBXO31) (Middle Region) Peptid

FBXO31 Reaktivität: Human Wirt: Synthetic BP, WB

Produktnummer ABIN976748

Kurzübersicht für F-Box Protein 31 (FBXO31) (Middle Region) Peptid (ABIN976748)

Target

FBXO31 (F-Box Protein 31 (FBXO31))

Spezies

Human

Quelle

Synthetic

Applikation

Blocking Peptide (BP), Western Blotting (WB)

Protein Region

Middle Region

Produktmerkmale

This is a synthetic peptide designed for use in combination with anti-FBXO31 antibody (Catalog #: ARP53776_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.

Aufreinigung

Purified
F-Box Protein 31 (FBXO31) peptide
FBXO31 Wirt: Synthetic BP, WB, IHC

F-Box Protein 31 (FBXO31) peptide
FBXO31 Wirt: Synthetic BP, WB, IHC

F-Box Protein 31 (FBXO31) (Middle Region) peptide
FBXO31 Reaktivität: Human Wirt: Synthetic BP, WB

Applikationshinweise

Each Investigator should determine their own optimal working dilution for specific applications.

Beschränkungen

Nur für Forschungszwecke einsetzbar
Format

Lyophilized

Rekonstitution

Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.

Konzentration

1 mg/mL

Buffer

Final peptide concentration is 1 mg/mL in PBS.

Handhabung

Avoid repeated freeze-thaw cycles.

Lagerung

-20 °C

Informationen zur Lagerung

For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
Target

FBXO31 (F-Box Protein 31 (FBXO31))

Hintergrund

FBXO31 is the component of some SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in G1 arrest following DNA damage. FBXO31 specifically recognizes phosphorylated cyclin-D1 (CCND1), promoting its ubiquitination and degradation by the proteasome, resulting in G1 arrest. FBXO31 may act as a tumor suppressor.Members of the F-box protein family, such as FBXO31, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1, MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM].

Alias Symbols: DKFZP434B027, DKFZp434J1815, FBX14, FBXO14, FLJ22477, Fbx31, MGC15419, MGC9527, pp2386

Protein Size: 367

Molekulargewicht

40 kDa

Gen-ID

79791

NCBI Accession

NM_024735, NP_079011

UniProt

Q5XUX0

Sie sind hier: