Coagulation Factor XI (F11) (C-Term) Peptid
F11
Reaktivität: Human
Wirt: Synthetic
BP, WB
Produktnummer ABIN976543
Kurzübersicht für Coagulation Factor XI (F11) (C-Term) Peptid (ABIN976543)
Target
Factor XI (F11)
(Coagulation Factor XI (F11))
Spezies
Human
Quelle
Synthetic
Applikation
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- C-Term
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Sequenz
- RHLCGGSIIG NQWILTAAHC FYGVESPKIL RVYSGILNQS EIKEDTSFFG
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Produktmerkmale
- This is a synthetic peptide designed for use in combination with anti-F11 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Aufreinigung
- Purified
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Applikationshinweise
- Each Investigator should determine their own optimal working dilution for specific applications.
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Lyophilized
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Rekonstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Konzentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handhabung
- Avoid repeated freeze-thaw cycles.
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Lagerung
- -20 °C
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Informationen zur Lagerung
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Factor XI (F11) (Coagulation Factor XI (F11))
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Hintergrund
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This gene encodes coagulation factor XI of the blood coagulation cascade. This protein is present in plasma as a zymogen, which is a unique plasma coagulation enzyme because it exists as a homodimer consisting of two identical polypeptide chains linked by disulfide bonds. During activation of the plasma factor XI, an internal peptide bond is cleaved by factor XIIa (or XII) in each of the two chains, resulting in activated factor XIa, a serine protease composed of two heavy and two light chains held together by disulfide bonds. This activated plasma factor XI triggers the middle phase of the intrisic pathway of blood coagulation by activating factor IX. Defects in this factor lead to Rosenthal syndrome, a blood coagulation abnormality.
Alias Symbols: FXI, MGC141891
Protein Interaction Partner: F11,F2,HGF,KNG1,SERPINA5,SERPINF2,TFPI2,KNG1,SERPINA5
Protein Size: 625 -
Molekulargewicht
- 70 kDa
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Gen-ID
- 2160
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NCBI Accession
- NM_000128, NP_000119
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UniProt
- P03951
Target
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