Egl-9 Family Hypoxia Inducible Factor 3 (EGLN3) Peptid
EGLN3
Reaktivität: Human, Maus
Wirt: Synthetic
BP, WB
Produktnummer ABIN976180
Kurzübersicht für Egl-9 Family Hypoxia Inducible Factor 3 (EGLN3) Peptid (ABIN976180)
Target
EGLN3
(Egl-9 Family Hypoxia Inducible Factor 3 (EGLN3))
Spezies
Human, Maus
Quelle
Synthetic
Applikation
Blocking Peptide (BP), Western Blotting (WB)
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Produktmerkmale
- This is a synthetic peptide designed for use in combination with anti-EGLN3 antibody (Catalog #: ARP52402_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Aufreinigung
- Purified
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Applikationshinweise
- Each Investigator should determine their own optimal working dilution for specific applications.
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Lyophilized
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Rekonstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Konzentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handhabung
- Avoid repeated freeze-thaw cycles.
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Lagerung
- -20 °C
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Informationen zur Lagerung
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- EGLN3 (Egl-9 Family Hypoxia Inducible Factor 3 (EGLN3))
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Hintergrund
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EGLN3 catalyzes the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. It hydroxylates HIF-1 alpha at 'Pro-564', and HIF-2 alpha. EGLN3 functions as a cellular oxygen sensor and, under normoxic conditions, targets HIF through the hydroxylation for proteasomal degradation via the von Hippel-Lindau ubiquitination complex. It may play a role in cell growth regulation in muscle cells and in apoptosis in neuronal tissue. EGLN3 promotes cell death through a caspase-dependent mechanism.
Alias Symbols: FLJ21620, HIFPH3, MGC125998, MGC125999, PHD3
Protein Interaction Partner: HIF1A,OS9,EPAS1,HIF1A,HIF3A,OS9,WDR83
Protein Size: 239 -
Molekulargewicht
- 27 kDa
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Gen-ID
- 112399
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NCBI Accession
- NM_022073, NP_071356
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UniProt
- Q9H6Z9
Target
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