Endothelin 3 (EDN3) (C-Term) Peptid
EDN3
Reaktivität: Human
Wirt: Synthetic
BP, WB
Produktnummer ABIN976135
Kurzübersicht für Endothelin 3 (EDN3) (C-Term) Peptid (ABIN976135)
Target
Endothelin 3 (EDN3)
Spezies
Human
Quelle
Synthetic
Applikation
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- C-Term
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Sequenz
- RYDKACLHFC TQTLDVSSNS RTAEKTDKEE EGKVRGANRG LCQRRLKSRT
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Produktmerkmale
- This is a synthetic peptide designed for use in combination with anti-EDN3 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Aufreinigung
- Purified
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Applikationshinweise
- Each Investigator should determine their own optimal working dilution for specific applications.
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Lyophilized
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Rekonstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Konzentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handhabung
- Avoid repeated freeze-thaw cycles.
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Lagerung
- -20 °C
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Informationen zur Lagerung
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Endothelin 3 (EDN3)
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Hintergrund
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The protein encoded by this gene is a member of the endothelin family. Endothelins are endothelium-derived vasoactive peptides involved in a variety of biological functions. The active form of this protein is a 21 amino acid peptide processed from the precursor protein. The active peptide is a ligand for endothelin receptor type B (EDNRB). The interaction of this endothelin with EDNRB is essential for development of neural crest-derived cell lineages, such as melanocytes and enteric neurons. Mutations in this gene and EDNRB have been associated with Hirschsprung disease (HSCR) and Waardenburg syndrome (WS), which are congenital disorders involving neural crest-derived cells. Four alternatively spliced transcript variants encoding three distinct isoforms have been observed.
Alias Symbols: ET3, MGC15067, MGC61498, ET-3, WS4B, HSCR4, PPET3
Protein Interaction Partner: CMA1,CTSE,EDNRA,EDNRB,KEL
Protein Size: 219 -
Molekulargewicht
- 24 kDa
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Gen-ID
- 1908
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NCBI Accession
- NM_207032, NP_996915
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UniProt
- Q7Z6D2
Target
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