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E2F Transcription Factor 7 (E2F7) (N-Term) Peptid

E2F7 Reaktivität: Human Wirt: Synthetic BP, WB
Produktnummer ABIN976085
  • Target Alle E2F7 Produkte
    E2F7 (E2F Transcription Factor 7 (E2F7))
    Protein Region
    N-Term
    Spezies
    Human
    Quelle
    • 6
    Synthetic
    Applikation
    Blocking Peptide (BP), Western Blotting (WB)
    Sequenz
    MEVNCLTLKD LISPRQTRLD FAIEDAENAQ KENIFVDRSR MTPKTPMKNE
    Produktmerkmale
    This is a synthetic peptide designed for use in combination with anti-E2F7 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
    Aufreinigung
    Purified
  • Applikationshinweise
    Each Investigator should determine their own optimal working dilution for specific applications.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Rekonstitution
    Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
    Konzentration
    1 mg/mL
    Buffer
    Final peptide concentration is 1 mg/mL in PBS.
    Handhabung
    Avoid repeated freeze-thaw cycles.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
  • Target
    E2F7 (E2F Transcription Factor 7 (E2F7))
    Synonyme
    E2F7 Peptide, E2F-7 Peptide, fc43h03 Peptide, si:dkey-217k21.2 Peptide, wu:fc43h03 Peptide, MGC154335 Peptide, A630014C11Rik Peptide, D10Ertd739e Peptide, E2F transcription factor 7 Peptide, E2F transcription factor 7 L homeolog Peptide, E2F7 Peptide, e2f7 Peptide, e2f7.L Peptide, E2f7 Peptide
    Hintergrund
    E2F7 is a atypical E2F transcription factor that participates in various processes such as angiogenesis, polyploidization of specialized cells and DNA damage response. E2F7 mainly acts as a transcription repressor that binds DNA independently of DP proteins and specifically recognizes the E2 recognition site 5'- TTTC[CG]CGC-3'. It directly represses transcription of classical E2F transcription factors such as E2F1. It acts as a regulator of S-phase by recognizing and binding the E2-related site 5'-TTCCCGCC-3' and mediating repression of G1/S-regulated genes. It plays a key role in polyploidization of cells in placenta and liver by regulating the endocycle, probably by repressing genes promoting cytokinesis and antagonizing action of classical E2F proteins (E2F1, E2F2 and/or E2F3). It is required for placental development by promoting polyploidization of trophoblast giant cells. Also involved in DNA damage response: up-regulated by p53/TP53 following genotoxic stress and acts as a downstream effector of p53/TP53-dependent repression by mediating repression of indirect p53/TP53 target genes involved in DNA replication. Acts as a promoter of sprouting angiogenesis, possibly by acting as a transcription activator: associates with HIF1A, recognizes and binds the VEGFA promoter.

    Alias Symbols: E2f7,

    Protein Size: 904
    Molekulargewicht
    99 kDa
    Gen-ID
    52679
    NCBI Accession
    XP_006513945
    UniProt
    Q6S7F2
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