Dishevelled Segment Polarity Protein 1 (DVL1) Peptid
DVL1
Reaktivität: Human
Wirt: Synthetic
BP, WB
Produktnummer ABIN976046
Kurzübersicht für Dishevelled Segment Polarity Protein 1 (DVL1) Peptid (ABIN976046)
Target
DVL1
(Dishevelled Segment Polarity Protein 1 (DVL1))
Spezies
Human
Quelle
Synthetic
Applikation
Blocking Peptide (BP), Western Blotting (WB)
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Produktmerkmale
- This is a synthetic peptide designed for use in combination with anti-DVL1 antibody (Catalog #: ARP32101_T100). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Aufreinigung
- Purified
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Applikationshinweise
- Each Investigator should determine their own optimal working dilution for specific applications.
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Lyophilized
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Rekonstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Konzentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handhabung
- Avoid repeated freeze-thaw cycles.
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Lagerung
- -20 °C
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Informationen zur Lagerung
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- DVL1 (Dishevelled Segment Polarity Protein 1 (DVL1))
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Hintergrund
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DVL1 is a cytoplasmic phosphoprotein that regulates cell proliferation, acting as a transducer molecule for developmental processes, including segmentation and neuroblast specification. DVL1 gene is a candidate for neuroblastomatous transformation. The Schwartz-Jampel syndrome and Charcot-Marie-Tooth disease type 2A have been mapped to the same region as DVL1 gene. The phenotypes of these diseases may be consistent with defects which might be expected from aberrant expression of a DVL gene during development.DVL1, the human homolog of the Drosophila dishevelled gene (dsh) encodes a cytoplasmic phosphoprotein that regulates cell proliferation, acting as a transducer molecule for developmental processes, including segmentation and neuroblast specification. DVL1 is a candidate gene for neuroblastomatous transformation. The Schwartz-Jampel syndrome and Charcot-Marie-Tooth disease type 2A have been mapped to the same region as DVL1. The phenotypes of these diseases may be consistent with defects which might be expected from aberrant expression of a DVL gene during development. Three transcript variants encoding three different isoforms have been found for this gene.
Alias Symbols: DVL, MGC54245, DVL1L1
Protein Interaction Partner: ARRB1,AXIN1,BRD7,CCDC88C,CSNK1D,CSNK1E,CSNK2A1,CTNNB1,CXXC4,DAAM1,DVL1,DVL3,DYNLT1,EPS8,FRAT1,HDHD2,HECW1,PPM1A,RAC1,SMAD2,SMAD3,SMAD4,SMAD7,USP13,VANGL1,VANGL2,ARRB1,ATN1,AXIN1,Axin1,CSNK1D,CSNK1E,CSNK2A1,CTNNB1,DAB2,DVL1,DVL3,EPS8,FRAT1,HECW1,SMAD1,SMAD2,SMAD3,SMAD4,SMAD7,USP13
Protein Size: 670 -
Molekulargewicht
- 73 kDa
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Gen-ID
- 1855
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NCBI Accession
- NM_004421, NP_004412
Target
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