Dickkopf 2 Homolog (DKK2) (C-Term) Peptid
DKK2
Reaktivität: Human, Maus
Wirt: Synthetic
BP, WB
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- Target Alle DKK2 Produkte
- DKK2 (Dickkopf 2 Homolog (DKK2))
- Protein Region
- C-Term
- Spezies
- Human, Maus
-
Quelle
- Synthetic
- Applikation
- Blocking Peptide (BP), Western Blotting (WB)
- Sequenz
- RTSDCGPGLC CARHFWTKIC KPVLREGQVC SRRGHKDTAQ APEIFQRCDC
- Produktmerkmale
- This is a synthetic peptide designed for use in combination with anti-Dkk4 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Aufreinigung
- Purified
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Dickkopf 2 Homolog (DKK2) peptide
DKK2 Reaktivität: Human, Maus, Rind (Kuh), Hund, Ratte Wirt: Synthetic BP, Imm
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- Applikationshinweise
- Each Investigator should determine their own optimal working dilution for specific applications.
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
-
- Format
- Lyophilized
- Rekonstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Konzentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handhabung
- Avoid repeated freeze-thaw cycles.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
-
- Target
- DKK2 (Dickkopf 2 Homolog (DKK2))
- Synonyme
- DKK-2 Peptide, Dkk4 Peptide, zgc:171574 Peptide, dickkopf WNT signaling pathway inhibitor 2 Peptide, DKK2 Peptide, Dkk2 Peptide, dkk2 Peptide
- Hintergrund
-
Dkk4 antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease.
Alias Symbols: Dkk-4, MGC25705
Protein Size: 221 - Molekulargewicht
- 24 kDa
- Gen-ID
- 234130
- NCBI Accession
- NM_145592, NP_663567
- UniProt
- Q8VEJ3
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