Cortactin (CTTN) Peptid
CTTN
Reaktivität: Human
Wirt: Synthetic
BP, WB, IHC
Produktnummer ABIN975451
Kurzübersicht für Cortactin (CTTN) Peptid (ABIN975451)
Target
Cortactin (CTTN)
Spezies
Human
Quelle
Synthetic
Applikation
Blocking Peptide (BP), Western Blotting (WB), Immunohistochemistry (IHC)
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Produktmerkmale
- This is a synthetic peptide designed for use in combination with anti-CTTN antibody (Catalog #: ARP52067_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Aufreinigung
- Purified
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Applikationshinweise
- Each Investigator should determine their own optimal working dilution for specific applications.
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Lyophilized
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Rekonstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Konzentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handhabung
- Avoid repeated freeze-thaw cycles.
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Lagerung
- -20 °C
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Informationen zur Lagerung
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Cortactin (CTTN)
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Hintergrund
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CTTN is overexpressed in breast cancer and squamous cell carcinomas of the head and neck. CTTN is localized in the cytoplasm and in areas of the cell-substratum contacts. It has two roles: (1) regulating the interactions between components of adherens-type junctions and (2) organizing the cytoskeleton and cell adhesion structures of epithelia and carcinoma cells. During apoptosis, CTTN is degraded in a caspase-dependent manner. The aberrant regulation of t CTTN contributes to tumor cell invasion and metastasis.This gene is overexpressed in breast cancer and squamous cell carcinomas of the head and neck. The encoded protein is localized in the cytoplasm and in areas of the cell-substratum contacts. This gene has two roles: (1) regulating the interactions between components of adherens-type junctions and (2) organizing the cytoskeleton and cell adhesion structures of epithelia and carcinoma cells. During apoptosis, the encoded protein is degraded in a caspase-dependent manner. The aberrant regulation of this gene contributes to tumor cell invasion and metastasis. Two splice variants that encode different isoforms have been identified for this gene.
Alias Symbols: EMS1, FLJ34459
Protein Interaction Partner: ARHGAP8,ACTA1,ACTR3,ANKZF1,CHD3,CTNND1,CTNND2,CTTN,CTTNBP2,DNM1,DNM2,FER,FGD1,GRB2,HAX1,HIP1R,KCNA2,MET,MYLK,NCF1,SDC3,SHANK2,SRC,SYK,TJP1,WIPF1,ACTR2,ACTR3,ARHGAP17,ARPC2,ARPC3,ARPC4,ASAP1,CASP3,CHD3,CRB2,CTNND1,FER,KCNA2,MYLK,PXN,SDC3,SHANK2,SYK,WASL,WIPF1
Protein Size: 550 -
Molekulargewicht
- 61 kDa
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Gen-ID
- 2017
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NCBI Accession
- NM_005231, NP_005222
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UniProt
- Q8N707
Target
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