Chemokine (C-C Motif) Receptor 5 (CCR5) (Middle Region) Peptid
CCR5
Reaktivität: Human
Wirt: Synthetic
BP, WB
Produktnummer ABIN974625
Kurzübersicht für Chemokine (C-C Motif) Receptor 5 (CCR5) (Middle Region) Peptid (ABIN974625)
Target
CCR5
(Chemokine (C-C Motif) Receptor 5 (CCR5))
Spezies
Human
Quelle
Synthetic
Applikation
Blocking Peptide (BP), Western Blotting (WB)
-
-
Protein Region
- Middle Region
-
Produktmerkmale
- This is a synthetic peptide designed for use in combination with anti-CCR5 antibody (Catalog #: ARP30788_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
-
Aufreinigung
- Purified
-
-
-
-
Applikationshinweise
- Each Investigator should determine their own optimal working dilution for specific applications.
-
Beschränkungen
- Nur für Forschungszwecke einsetzbar
-
-
-
Format
- Lyophilized
-
Rekonstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
-
Konzentration
- 1 mg/mL
-
Buffer
- Final peptide concentration is 1 mg/mL in PBS.
-
Handhabung
- Avoid repeated freeze-thaw cycles.
-
Lagerung
- -20 °C
-
Informationen zur Lagerung
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
-
-
- CCR5 (Chemokine (C-C Motif) Receptor 5 (CCR5))
-
Hintergrund
-
CCR5 is a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. The protein is expressed by T cells and macrophages, and is known to be an important co-receptor for macrophage-tropic virus, including HIV, to enter host cells. Defective alleles of this gene have been associated with the HIV infection resistance. The ligands of this receptor include monocyte chemoattractant protein 2 (MCP-2), macrophage inflammatory protein 1 alpha (MIP-1 alpha), macrophage inflammatory protein 1 beta (MIP-1 beta) and regulated on activation normal T expressed and secreted protein (RANTES). Expression of this protein was also detected in a promyeloblastic cell line, suggesting that CCR5 may play a role in granulocyte lineage proliferation and differentiation. This gene is located at the chemokine receptor gene cluster region. Two transcript variants encoding the same protein have been found for this gene.This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. This protein is expressed by T cells and macrophages, and is known to be an important co-receptor for macrophage-tropic virus, including HIV, to enter host cells. Defective alleles of this gene have been associated with the HIV infection resistance. The ligands of this receptor include monocyte chemoattractant protein 2 (MCP-2), macrophage inflammatory protein 1 alpha (MIP-1 alpha), macrophage inflammatory protein 1 beta (MIP-1 beta) and regulated on activation normal T expressed and secreted protein (RANTES). Expression of this gene was also detected in a promyeloblastic cell line, suggesting that this protein may play a role in granulocyte lineage proliferation and differentiation. This gene is located at the chemokine receptor gene cluster region. Two transcript variants encoding the same protein have been found for this gene.
Alias Symbols: CC-CKR-5, CCCKR5, CD195, CKR-5, CKR5, CMKBR5, IDDM22
Protein Interaction Partner: ADRBK1,ADRBK2,AFP,ARL6IP5,ARRB1,CCL11,CCL13,CCL14,CCL16,CCL2,CCL3,CCL3L1,CCL3L3,CCL4,CCL5,CCL7,CCL8,CCR2,CCR5,CD4,CXCR4,DNM2,GNAI1,GNAI2,GNAI3,GNAO1,GNAQ,JAK1,JAK2,LCK,ORM1,PRAF2,PSMA5,PTK2,PTK2B,STAT1,STAT3,STAT5A,TXK,AFP,ARRB1,CCL3,CCL3L1,CCL5,CD4,CXCR4,JAK2,PIK3R2,PTK2,STAT3,STAT5B
Protein Size: 352 -
Molekulargewicht
- 41 kDa
-
Gen-ID
- 1234
-
NCBI Accession
- NM_000579, NP_000570
-
UniProt
- P51681
Target
-
Sie sind hier:
