Caspase 3 (CASP3) (C-Term) Peptid
CASP3
Reaktivität: Human
Wirt: Synthetic
BP, WB, IHC
Produktnummer ABIN974474
Kurzübersicht für Caspase 3 (CASP3) (C-Term) Peptid (ABIN974474)
Target
Caspase 3 (CASP3)
Spezies
Human
Quelle
Synthetic
Applikation
Blocking Peptide (BP), Western Blotting (WB), Immunohistochemistry (IHC)
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Protein Region
- C-Term
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Sequenz
- NLKYEVRNKN DLTREEIVEL MRDVSKEDHS KRSSFVCVLL SHGEEGIIFG
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Produktmerkmale
- This is a synthetic peptide designed for use in combination with anti-CASP3 Antibody(ARP58987_P050),. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Aufreinigung
- Purified
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Applikationshinweise
- Each Investigator should determine their own optimal working dilution for specific applications.
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Lyophilized
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Rekonstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Konzentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handhabung
- Avoid repeated freeze-thaw cycles.
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Lagerung
- -20 °C
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Informationen zur Lagerung
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Caspase 3 (CASP3)
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Hintergrund
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CASP3 is a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. Alternative splicing of this gene results in two transcript variants that encode the same protein.
Alias Symbols: CPP32, CPP32B, SCA-1
Protein Interaction Partner: AR,ATN1,ATXN3,BIRC3,BIRC6,HTT,NDUFS1,NEO1,PARP1,PLEKHO1,XIAP,BIRC6,CFLAR,PSEN1,RB1,XIAP,ACIN1,ADD1,AIFM1,AKAP8,AKT1,APAF1,APP,AR,ARHGDIB,ATN1,BCAP31,BCAR1,BCL2,BID,BIRC2,BIRC3,BIRC5,BIRC6,BIRC7,BLM,BMX,BRCA1,CAD,CASP10,CASP3,CASP4,CASP6,CASP8,CASP9,CAST,C
Protein Size: 277 -
Molekulargewicht
- 12 kDa
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Gen-ID
- 836
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NCBI Accession
- NM_032991, NP_116786
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UniProt
- P42574
Target
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