Androgen Receptor (AR) (N-Term) Peptid
AR
Reaktivität: Human
Wirt: Synthetic
BP, WB
Kurzübersicht für Androgen Receptor (AR) (N-Term) Peptid (ABIN973356)
Target
Androgen Receptor (AR)
Spezies
Human
Quelle
Synthetic
Applikation
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- N-Term
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Produktmerkmale
- This is a synthetic peptide designed for use in combination with anti-AR antibody (Catalog #: ARP30974_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Aufreinigung
- Purified
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Androgen Receptor (AR) peptide
AR Reaktivität: Human, Maus, Ratte, Rind (Kuh), Hund, Schwein Wirt: Synthetic BP, Imm
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Applikationshinweise
- Each Investigator should determine their own optimal working dilution for specific applications.
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Lyophilized
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Rekonstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Konzentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handhabung
- Avoid repeated freeze-thaw cycles.
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Lagerung
- -20 °C
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Informationen zur Lagerung
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Androgen Receptor (AR)
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Hintergrund
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AR has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract causes spinal bulbar muscular atrophy (Kennedy disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS).The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract causes spinal bulbar muscular atrophy (Kennedy disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS). Two alternatively spliced variants encoding distinct isoforms have been described.
Alias Symbols: AIS, DHTR, HUMARA, KD, NR3C4, SBMA, SMAX1, TFM, HYSP1
Protein Interaction Partner: AKT1,CASP1,CASP3,CASP7,CASP8,CAV1,FGF8,KLK2,KLK3,NCOA1,NCOA1,NCOA2,RB1,TGFB1I1,AES,AHR,AKT1,APOL2,APPBP2,AR,ATF2,BAG1,BRCA1,CALM1,CALR,CASP1,CASP3,CASP7,CASP8,CAV1,CCND1,CCNE1,CCNH,CDC25A,CDC25B,CDC37,CDK1,CDK6,CDK7,CDK9,COX5B,CREBBP,CTDSP2,CTNNB1,CUL4B,DAP3,DAXX,DCAF6,DDC,EFCAB6,EGFR,EP300,ESR1,ETV5,FHL2,FLNA,FOXA1,FOXO1,GAK,GAPDH,GNB2L1,GRIP1,GSK3B,GSN,GTF2F1,GTF2F2,GTF2H1,HDAC1,HIF1A,HIPK3,HMGB1,HSP90AA1,IARS,IDE,IFI16,IL6ST,JMJD1C,JUN,KAT2B,KAT5,KDM1A,KIF1A,KLK2,MAPK1,MDM2,MED1,MED14,MYBBP1A,MYST2,NCOA1,NCOA2,NCOA3,NCOA4,NCOR1,NCOR2,NFKB1,NISCH,NONO,NR0B1,NR0B2,NR2C1,NR2C2,NR3C1,NR3C2,NR5A1,NRIP1,NSD1,PA2G4,PAK6,PIAS1,PIAS2,PIAS3,PIAS4,PNRC1,PNRC2,POU2F1,POU5F1,PRMT1,PSMC3IP,PTEN,PXN,RAC3,RAD54L2,RAD9A,RAF1,RAN,RANBP9,RB1,RBAK,RCHY1,RELA,RNASEL,RNF14,RNF4,RUNX1,RUNX2,SART3,SLC25A4,SMAD1,SMAD3,SMAD4,SP1,SPDEF,SRC,SRY,STAT3,STUB1,SUMO1,SVIL,TCF4,TGFB1I1,TGIF1,TMF1,TRIM24,TRIP4,TSG101,UBE2I,UBE3A,UXT,WIPI1,XRCC5,XRCC6,ZMIZ1,AES,AKT1,AR,BAG1,BRCA1,CALM1,CALR,CAV1,CCND1,CCNE1,CCNH,CDC25B,CDC37,CDK7,CDK9,CEBPA,CEBPB,COX5B,CREBBP,CTNNB1,DAP3,DAXX,DCC,EFCAB6,EGFR,ETV5,FHL2,FLNA,FOXA1,FOXO1,GAPDH,GNB2L1,GRIP1,GSK3A,GSK3B,GSN,GTF2F1,GTF2F2,GTF2H1,HDAC1,HDAC3,HDAC4,HMGB1,HMGB2,HNF4A,HSP90AA1,HSPA1A,HSPB2,IL6ST,JUN,KAT5,MAGEA11,MAPK1,MDM2,MED1,MYST2,NCOA1,NCOA2,NCOA3,NCOA4,NCOA6,NCOR1,NCOR2,NONO,NR0B1,NR0B2,NR2C1,NR2C2,NSD1,PA2G4,PAK6,PATZ1,PELP1,PIAS1,PIAS2,PIAS3,PIAS4,PMEPA1,POU2F1,POU2F2,PRKDC,PRMT1,PRPF6,PSPC1,PTEN,RAD9A,RAF1,RAN,RANBP9,RB1,RCHY1,RNF14,RNF4,SART3,SELENBP1,SMAD3,SMAD4,SMARCA4,SMARCC1,SP1,SPDEF,SRC,SRY,STAT3,SVIL,TBP,TCF4,TDG,TGFB1I1,TMF1,TP53,TRIM24,TRIM68,TSG101,UBC,UBE2I,UXT,XRCC5,XRCC6,YWHAQ,ZMIZ1
Protein Size: 920 -
Molekulargewicht
- 99 kDa
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Gen-ID
- 367
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NCBI Accession
- NM_000044, NP_000035
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UniProt
- P10275
Target
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