Amyloid beta (A4) Precursor Protein (APP) (Middle Region) Peptid
APP
Reaktivität: Human
Wirt: Synthetic
BP, WB
Kurzübersicht für Amyloid beta (A4) Precursor Protein (APP) (Middle Region) Peptid (ABIN973341)
Target
APP
(Amyloid beta (A4) Precursor Protein (APP))
Spezies
Human
Quelle
Synthetic
Applikation
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- Middle Region
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Sequenz
- SQVMREWEEA ERQAKNLPKA DKKAVIQHFQ EKVESLEQEA ANERQQLVET
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Produktmerkmale
- This is a synthetic peptide designed for use in combination with anti- APP Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Aufreinigung
- Purified
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Applikationshinweise
- Each Investigator should determine their own optimal working dilution for specific applications.
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Lyophilized
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Rekonstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Konzentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handhabung
- Avoid repeated freeze-thaw cycles.
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Lagerung
- -20 °C
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Informationen zur Lagerung
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- APP (Amyloid beta (A4) Precursor Protein (APP))
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Hintergrund
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This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. In addition, two of the peptides are antimicrobial peptides, having been shown to have bacteriocidal and antifungal activities. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene.
Alias Symbols: AAA, AD1, PN2, ABPP, APPI, CVAP, ABETA, PN-II, CTFgamma
Protein Size: 714 -
Molekulargewicht
- 85 kDa
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Gen-ID
- 351
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NCBI Accession
- NM_001136130, NP_001129602
Target
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