Apurinic/Apyrimidinic Endonuclease 1 (APEX1) Peptid
APEX1
Reaktivität: Human
Wirt: Synthetic
BP, WB, IHC
Produktnummer ABIN973297
Kurzübersicht für Apurinic/Apyrimidinic Endonuclease 1 (APEX1) Peptid (ABIN973297)
Target
APEX1
(Apurinic/Apyrimidinic Endonuclease 1 (APEX1))
Spezies
Human
Quelle
Synthetic
Applikation
Blocking Peptide (BP), Western Blotting (WB), Immunohistochemistry (IHC)
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Produktmerkmale
- This is a synthetic peptide designed for use in combination with anti-APEX1 antibody (Catalog #: ARP32651_T100). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Aufreinigung
- Purified
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Applikationshinweise
- Each Investigator should determine their own optimal working dilution for specific applications.
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Lyophilized
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Rekonstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Konzentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handhabung
- Avoid repeated freeze-thaw cycles.
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Lagerung
- -20 °C
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Informationen zur Lagerung
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- APEX1 (Apurinic/Apyrimidinic Endonuclease 1 (APEX1))
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Hintergrund
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Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre-mutagenic lesions that can prevent normal DNA replication so the cell contains systems to identify and repair such sites. Class II AP endonucleases cleave the phosphodiester backbone 5' to the AP site. This gene encodes the major AP endonuclease in human cells.
Alias Symbols: APE, APX, APE1, APEN, APEX, HAP1, REF1
Protein Interaction Partner: CDKN1A,MUTYH,TP53,ANP32A,ANP32C,APEX1,CSNK2A1,DCTN1,EP300,FEN1,GZMA,HDAC1,HIF1A,HMGB2,HNRNPL,HSPA1A,MUTYH,NME1,NXF2,PCNA,POLB,SET,TP53,TXN,UBE2I,XRCC1,XRCC6,ANP32A,FEN1,HIF1A,HNRNPL,MUTYH,PCNA,SET,TP53,XRCC1,XRCC5
Protein Size: 318 -
Molekulargewicht
- 35 kDa
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Gen-ID
- 328
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NCBI Accession
- NM_080648, NP_542379
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UniProt
- P27695
Target
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