Amyotrophic Lateral Sclerosis 2 (Juvenile) (ALS2) (Middle Region) Peptid
ALS2
Reaktivität: Human
Wirt: Synthetic
BP, WB
Produktnummer ABIN973149
150,78 €
Zzgl. Versandkosten 20,00 € und MwSt
100 μg
Lieferung nach:
Deutschland
Lieferung in 15 bis 22 Werktagen
Kurzübersicht für Amyotrophic Lateral Sclerosis 2 (Juvenile) (ALS2) (Middle Region) Peptid (ABIN973149)
Target
ALS2
(Amyotrophic Lateral Sclerosis 2 (Juvenile) (ALS2))
Spezies
Human
Quelle
Synthetic
Applikation
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- Middle Region
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Sequenz
- ALRGMSDLPP YGSGSSVQRQ EPPISRSAKY TFYKDPRLKD ATYDGRWLSG
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Produktmerkmale
- This is a synthetic peptide designed for use in combination with anti-ALS2 Antibody(ARP57487_P050),. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Aufreinigung
- Purified
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Applikationshinweise
- Each Investigator should determine their own optimal working dilution for specific applications.
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Lyophilized
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Rekonstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Konzentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handhabung
- Avoid repeated freeze-thaw cycles.
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Lagerung
- -20 °C
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Informationen zur Lagerung
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- ALS2 (Amyotrophic Lateral Sclerosis 2 (Juvenile) (ALS2))
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Hintergrund
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The protein encoded by this gene contains an ATS1/RCC1-like domain, a RhoGEF domain, and a vacuolar protein sorting 9 (VPS9) domain, all of which are guanine-nucleotide exchange factors that activate members of the Ras superfamily of GTPases. The protein functions as a guanine nucleotide exchange factor for the small GTPase RAB5. The protein localizes with RAB5 on early endosomal compartments, and functions as a modulator for endosomal dynamics. Mutations in this gene result in several forms of juvenile lateral sclerosis and infantile-onset ascending spastic paralysis. Multiple transcript variants encoding different isoforms have been found for this gene.
Alias Symbols: ALS2CR6, ALSJ, FLJ31851, IAHSP, KIAA1563, MGC87187, PLSJ
Protein Interaction Partner: YWHAB
Protein Size: 1657 -
Molekulargewicht
- 184 kDa
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Gen-ID
- 57679
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NCBI Accession
- NM_020919, NP_065970
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UniProt
- Q96Q42
Target
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