Autoimmune Regulator (AIRE) Peptid
AIRE
Reaktivität: Human
Wirt: Synthetic
BP, WB, IHC
Produktnummer ABIN973041
150,78 €
Zzgl. Versandkosten 20,00 € und MwSt
100 μg
Lieferung nach:
Deutschland
Lieferung in 15 bis 22 Werktagen
Kurzübersicht für Autoimmune Regulator (AIRE) Peptid (ABIN973041)
Target
AIRE
(Autoimmune Regulator (AIRE))
Spezies
Human
Quelle
Synthetic
Applikation
Blocking Peptide (BP), Western Blotting (WB), Immunohistochemistry (IHC)
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Produktmerkmale
- This is a synthetic peptide designed for use in combination with anti-AIRE antibody (Catalog #: ARP32650_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Aufreinigung
- Purified
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Applikationshinweise
- Each Investigator should determine their own optimal working dilution for specific applications.
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Lyophilized
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Rekonstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Konzentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handhabung
- Avoid repeated freeze-thaw cycles.
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Lagerung
- -20 °C
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Informationen zur Lagerung
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- AIRE (Autoimmune Regulator (AIRE))
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Hintergrund
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The function of the protein encoded by the AIRE gene is not well defined. However it contains zinc finger motifs suggestive of a transcription factor. The protein (isoform 1) is localized to both the nucleus and cytoplasm. Defects in this gene cause the autosomal-recessive systemic autoimmune disease termed autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED).This gene encodes a transcriptional regulator that forms nuclear bodies and interacts with the transcriptional coactivator CBP. At least three splice variant mRNAs products have been described including one which results in a premature stop codon and a transcript predicted to be a candidate for nuclear-mediated decay (NMD). Defects in this gene cause the rare autosomal-recessive systemic autoimmune disease termed autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED).
Alias Symbols: AIRE1, APECED, APS1, APSI, PGA1
Protein Interaction Partner: AIRE,CREBBP,AIRE,CREBBP,AIRE,CHD6,CREBBP,DDX17,DDX5,EFTUD2,GEMIN5,HIST1H2AC,HIST1H2BO,IPO7,KPNB1,LMNB1,MCM2,MCM5,MCM6,MSH2,MSH6,MYBBP1A,NASP,NOP56,NUP93,PABPC1,PARP1,PCNA,POLR2A,POLR2B,PRKDC,RAD21,RANBP2,RANBP9,RUVBL2,SMC1A,SMC3,SNRPB,SNRPD3,SRSF1,SRSF2,SRSF3,SSRP1,TOP2A,TRIM28,XPO1,XPOT
Protein Size: 545 -
Molekulargewicht
- 58 kDa
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Gen-ID
- 326
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NCBI Accession
- NM_000383, NP_000374
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UniProt
- O43918
Target
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