Actinin, alpha 1 (ACTN1) (N-Term) Peptid
ACTN1
Reaktivität: Human
Wirt: Synthetic
BP, WB, IHC
Produktnummer ABIN972864
Kurzübersicht für Actinin, alpha 1 (ACTN1) (N-Term) Peptid (ABIN972864)
Target
ACTN1
(Actinin, alpha 1 (ACTN1))
Spezies
Human
Quelle
Synthetic
Applikation
Blocking Peptide (BP), Western Blotting (WB), Immunohistochemistry (IHC)
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Protein Region
- N-Term
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Produktmerkmale
- This is a synthetic peptide designed for use in combination with anti-ACTN1 antibody (Catalog #: ARP58413_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Aufreinigung
- Purified
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Applikationshinweise
- Each Investigator should determine their own optimal working dilution for specific applications.
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Lyophilized
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Rekonstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Konzentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handhabung
- Avoid repeated freeze-thaw cycles.
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Lagerung
- -20 °C
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Informationen zur Lagerung
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- ACTN1 (Actinin, alpha 1 (ACTN1))
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Hintergrund
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Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, cytoskeletal, alpha actinin isoform and maps to the same site as the structurally similar erythroid beta spectrin gene. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: FLJ40884
Protein Interaction Partner: HCVgp1,PDLIM1,TRAF4,ACTN1,ADORA2A,ATXN2,CAMK2A,CDK5,CDK5R1,CDK5R2,CLIC5,COIL,COL17A1,CSRP1,CSRP3,CTNNA1,FBP1,FXN,GFI1B,GIPC1,GRIA4,GRIN2A,KAT2B,LPP,MAGEA11,MED14,MYOT,MYOZ1,MYOZ2,MYOZ3,NEBL,NR1H3,PALLD,PDLIM1,PDLIM5,PKD1,PKN1,PLD2,PTK2,PTPN1,PTPN6,PYGB,RAVER1,SLC2A4,SRC,SSX2IP,TES,TTN,VCL,XRCC4,ZYX,ACTN1,CDH1,CDK5R1,CDK5R2,COL17A1,CTNNA1,GIPC1,ITGB1,MAGEA11,MYOT,MYOZ1,PDLIM1,PHB,PKN1,PYGB,SSX2IP,TTN,XRCC4,ZYX
Protein Size: 892 -
Molekulargewicht
- 103 kDa
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Gen-ID
- 87
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NCBI Accession
- NM_001102, NP_001093
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UniProt
- P12814
Target
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