APOBEC1 Complementation Factor (A1CF) (N-Term) Peptid
A1CF
Reaktivität: Human
Wirt: Synthetic
BP, WB
Produktnummer ABIN972679
Kurzübersicht für APOBEC1 Complementation Factor (A1CF) (N-Term) Peptid (ABIN972679)
Target
A1CF
(APOBEC1 Complementation Factor (A1CF))
Spezies
Human
Quelle
Synthetic
Applikation
Blocking Peptide (BP), Western Blotting (WB)
-
-
Protein Region
- N-Term
-
Produktmerkmale
- This is a synthetic peptide designed for use in combination with anti-A1CF antibody (Catalog #: ARP41109_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
-
Aufreinigung
- Purified
-
-
-
-
Applikationshinweise
- Each Investigator should determine their own optimal working dilution for specific applications.
-
Beschränkungen
- Nur für Forschungszwecke einsetzbar
-
-
-
Format
- Lyophilized
-
Rekonstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
-
Konzentration
- 1 mg/mL
-
Buffer
- Final peptide concentration is 1 mg/mL in PBS.
-
Handhabung
- Avoid repeated freeze-thaw cycles.
-
Lagerung
- -20 °C
-
Informationen zur Lagerung
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
-
-
- A1CF (APOBEC1 Complementation Factor (A1CF))
-
Hintergrund
-
Mammalian apolipoprotein B mRNA undergoes site-specific C to U deamination, which is mediated by a multi-component enzyme complex containing a minimal core composed of APOBEC-1 and a complementation factor encoded by this gene. A1CF has three non-identical RNA recognition motifs and belongs to the hnRNP R family of RNA-binding proteins. It has been proposed that this complementation factor functions as an RNA-binding subunit and docks APOBEC-1 to deaminate the upstream cytidine. Studies suggest that the protein may also be involved in other RNA editing or RNA processing events. Alternative splicing occurs at this locus and three full-length transcript variants, encoding three distinct isoforms, have been described. Additional splicing has been observed but the full-length nature of these variants has not been determined.Mammalian apolipoprotein B mRNA undergoes site-specific C to U deamination, which is mediated by a multi-component enzyme complex containing a minimal core composed of APOBEC-1 and a complementation factor encoded by this gene. The gene product has three non-identical RNA recognition motifs and belongs to the hnRNP R family of RNA-binding proteins. It has been proposed that this complementation factor functions as an RNA-binding subunit and docks APOBEC-1 to deaminate the upstream cytidine. Studies suggest that the protein may also be involved in other RNA editing or RNA processing events. Alternative splicing occurs at this locus and three full-length transcript variants, encoding three distinct isoforms, have been described. Additional splicing has been observed but the full-length nature of these variants has not been determined.
Alias Symbols: ACF, ACF64, ACF65, APOBEC1CF, ASP, MGC163391, RP11-564C4.2
Protein Interaction Partner: APOBEC1,CELF2,KHSRP,SYNCRIP,TNPO2,APOBEC1,CELF2,KHSRP,SYNCRIP,TNPO2
Protein Size: 594 -
Molekulargewicht
- 65 kDa
-
Gen-ID
- 29974
-
NCBI Accession
- NM_138933, NP_620311
-
UniProt
- Q9NQ94
Target
-
Sie sind hier:
