A synthetic peptide for use as a blocking control in assays to test for specificity of RAD18 antibody, Alternative Names: RAD18 control peptide, RAD18 antibody Blocking Peptide, Anti-RAD18 Blocking Peptide, Rad18 Homolog Blocking Peptide, RNF73 Blocking Peptide, RAD18, RAD-18, RAD 18, RAD-18 Blocking Peptide, RAD 18 Blocking Peptide
RAD18
Reaktivität: Human, Affe, Schwein
Wirt: Synthetic
BP
Applikationshinweise
Optimal conditions should be determined by the investigator
Beschränkungen
Nur für Forschungszwecke einsetzbar
Format
Lyophilized
Rekonstitution
Add 100 µL of distilled water for a final peptide concentration is 1 mg/mL.
Buffer
PBS
Handhabung
Avoid repeated freeze/thaw cycles.
Lagerung
-20 °C
Informationen zur Lagerung
Store at -20 °C long term.
Target
RAD18
(E3 ubiquitin-protein ligase RAD18 (RAD18))
Synonyme
RNF73 Peptide, 2810024C04Rik Peptide, Rad18sc Peptide, zgc:55577 Peptide, RAD18 Peptide, DDBDRAFT_0218120 Peptide, DDBDRAFT_0304878 Peptide, DDB_0218120 Peptide, DDB_0304878 Peptide, DKFZp469H0810 Peptide, RAD18, E3 ubiquitin protein ligase Peptide, RAD18 E3 ubiquitin protein ligase Peptide, E3 ubiquitin-protein ligase RAD18 Peptide, E3 ubiquitin-protein ligase Peptide, DNA repair protein and ATPase Peptide, C3HC4-type zinc finger-containing protein Peptide, RAD18 Peptide, Rad18 Peptide, rad18 Peptide
Hintergrund
RAD18 is highly similar to S. cerevisiae DNA damage repair protein Rad18. Yeast Rad18 functions through its interaction with Rad6, which is an ubiquitin-conjugating enzyme required for post-replication repair of damaged DNA. Similar to its yeast counterpart, RAD18 is able to interact with the human homolog of yeast Rad6 protein through a conserved ring-finger motif. Mutation of this motif results in defective replication of UV-damaged DNA and hypersensitivity to multiple mutagens.