A synthetic peptide for use as a blocking control in assays to test for specificity of EIF4 G2 antibody, Alternative Names: EIF4G2 control peptide, EIF4G2 antibody Blocking Peptide, Anti-EIF4G2 Blocking Peptide, Eukaryotic Translation Initiation Factor 4 Gamma 2 Blocking Peptide, EIF4G2, EIFG2-4, EIFG2 4, EIFG2-4 Blocking Peptide, EIFG2 4 Blocking Peptide
Translation initiation is mediated by specific recognition of the cap structure by eukaryotic translation initiation factor 4F (eIF4F), which is a cap binding protein complex that consists of three subunits: eIF4A, eIF4E and eIF4G. EIF4G2 shares similarity with the C-terminal region of eIF4G that contains the binding sites for eIF4A and eIF3, eIF4G, in addition, contains a binding site for eIF4E at the N-terminus. Unlike eIF4G, which supports cap-dependent and independent translation, EIF4G2 functions as a general repressor of translation by forming translationally inactive complexes.