A synthetic peptide for use as a blocking control in assays to test for specificity of AUH antibody, Alternative Names: AUH control peptide, AUH antibody Blocking Peptide, Anti-AUH Blocking Peptide, Au Rna Binding Protein/Enoyl-Coenzyme A Hydratase Blocking Peptide
AU-specific RNA-binding enoyl-CoA hydratase (AUH) protein binds to the AU-rich element (ARE), a common element found in the 3' UTR of rapidly decaying mRNA such as c-fos, c-myc and granulocyte/ macrophage colony stimulating factor. ARE elements are involved in directing RNA to rapid degradation and deadenylation. AUH is also homologous to enol-CoA hydratase, an enzyme involved in fatty acid degradation, and has been shown to have intrinsic hydratase enzymatic activity. AUH is thus a bifunctional chimera between RNA binding and metabolic enzyme activity.