3-hydroxyanthranilate 3,4-Dioxygenase (HAAO) Peptid
HAAO
Reaktivität: Säugetier
Wirt: Synthetic
BP, WB, IHC
Produktnummer ABIN939222
Kurzübersicht für 3-hydroxyanthranilate 3,4-Dioxygenase (HAAO) Peptid (ABIN939222)
Target
HAAO
(3-hydroxyanthranilate 3,4-Dioxygenase (HAAO))
Spezies
Säugetier
Quelle
Synthetic
Applikation
Blocking Peptide (BP), Western Blotting (WB), Immunohistochemistry (IHC)
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Protein-Typ
- Synthetic
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Sequenz
- HRDVVIRQGE IFLLPARVPH SPQRFANTVG LVVERRRLET ELDGLRYYVG
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Produktmerkmale
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A synthetic peptide for use as a blocking control in assays to test for specificity of HAAO antibody,
Alternative Names: HAAO control peptide, HAAO antibody Blocking Peptide, Anti-HAAO Blocking Peptide, 3-Hydroxyanthranilate 34-Dioxygenase Blocking Peptide, 3-HAO Blocking Peptide, HAO Blocking Peptide
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Applikationshinweise
- Optimal conditions should be determined by the investigator
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Lyophilized
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Rekonstitution
- Add 100 µL of distilled water for a final peptide concentration is 1 mg/mL.
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Buffer
- PBS
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Handhabung
- Avoid repeated freeze/thaw cycles.
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Lagerung
- -20 °C
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Informationen zur Lagerung
- Store at -20 °C long term.
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- HAAO (3-hydroxyanthranilate 3,4-Dioxygenase (HAAO))
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Hintergrund
- 3-Hydroxyanthranilate 3,4-dioxygenase is a monomeric cytosolic protein belonging to the family of intramolecular dioxygenases containing nonheme ferrous iron. It is widely distributed in peripheral organs, such as liver and kidney, and is also present in low amounts in the central nervous system. HAAO catalyzes the synthesis of quinolinic acid (QUIN) from 3-hydroxyanthranilic acid. QUIN is an excitotoxin whose toxicity is mediated by its ability to activate glutamate N-methyl-D-aspartate receptors. Increased cerebral levels of QUIN may participate in the pathogenesis of neurologic and inflammatory disorders.
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Molekulargewicht
- 32 kDa
Target
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